Anti-Inflammatory Activity of Cell-Penetrating Peptide Nucleic Acids Targeting Indoleamine 2,3-Dioxygenase 1 in IFNγ-Treated Human Keratinocytes.

Daram Jung, Sungjin Ahn, In Guk Park, Yeasel Jeon, Sangbong Lee, Minsoo Noh

Abstract read

In one paragraph

Article in Biomolecules & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Daram JungNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

Sungjin AhnNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

In Guk ParkNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

Yeasel JeonOliPass Corporation, Yongin 17015, Republic of Korea.

Sangbong LeeOliPass Corporation, Yongin 17015, Republic of Korea.

Minsoo NohNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that plays a pivotal role in immune regulation by metabolizing tryptophan into kynurenine, leading to T cell suppression and promoting immune tolerance. However, persistent activation of IDO1 can lead to prolonged immune stimulation in inflammatory conditions such as skin diseases and chronic inflammation. In this study, we developed modified peptide nucleic acids (PNAs) conjugated with cationic lipid chains to target IDO1 pre-mRNA and evaluated their anti-inflammatory effects in human keratinocytes. The modified PNAs demonstrated enhanced solubility, robust binding affinity, and effective penetration into keratinocytes. Quantitative PCR results showed significant downregulation of IDO1 and pro-inflammatory cytokines such as IL-6, IL-8, and PTGS2 in interferon γ (IFNγ)-treated keratinocytes. These findings suggest that cell-penetrating PNAs targeting IDO1 hold potential as a therapeutic approach for inflammatory skin disorders and chronic inflammation.

Indexed as

3-Dioxygenase 1Anti-inflammationAntisense oligonucleotidesCell penetrationIndoleamine 2Normal human keratinocytesPeptide nucleic acids

Identifiers

PMID40275566

DOI10.4062/biomolther.2024.207

PMCPMC12059366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.