Evidence map›Paper›PMID 40275557›Full record

ReviewAsian journal of andrology2025

Diagnostic algorithm in men suspected with nonobstructive azoospermia.

Mahdi Bazzi, Matthew Chabot, Amarnath Rambhatla, Eric Chung

Abstract readReview
In one paragraph

Review in Asian journal of andrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mahdi BazziVattikuti Urology Institute, Henry Ford Health System, Detroit, MI 48202, USA.
Matthew ChabotVattikuti Urology Institute, Henry Ford Health System, Detroit, MI 48202, USA.
Amarnath RambhatlaVattikuti Urology Institute, Henry Ford Health System, Detroit, MI 48202, USA.
Eric ChungThe University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractThis review focuses on the diagnostic algorithm for nonobstructive azoospermia (NOA), a significant male factor contributing to infertility. NOA, characterized by the absence of sperm in the ejaculate, requires a systematic diagnostic approach to identify reversible conditions, genetic factors, and prognosis for achieving pregnancy. The diagnostic pathway involves semen analysis and a comprehensive evaluation for hormonal deficiencies, anatomical abnormalities, and genetic factors. The importance of medical history, physical examination, endocrine evaluation, imaging, and genetic testing is emphasized. This review highlights the significance of differentiating NOA from obstructive azoospermia (OA) and outlines key considerations for effective management, including surgical sperm retrieval and assisted reproductive techniques. Testicular biopsy is discussed as a definitive method to distinguish obstructive cases from nonobstructive cases, providing valuable prognostic information. Overall, a thorough and systematic diagnostic approach is essential for the effective management of men suspected with NOA, offering insights into potential treatment options and reproductive outcomes.

Indexed as

AlgorithmsAzoospermiaBiopsyHumansInfertility, MaleMaleSemen AnalysisSperm RetrievalTestisfollicle-stimulating hormone receptorluteinizing hormonenonobstructive azoospermiasemen

Identifiers

PMID40275557
PMCPMC12112923

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.