Evidence map›Paper›PMID 40275476›Full record

ArticleObesity (Silver Spring, Md.)2025

Grandmaternal perinatal serum polychlorinated biphenyls and prevalence of obesity in adult daughters and granddaughters.

Barbara A Cohn, Piera M Cirillo, Michele A La Merrill, Caitlin C Murphy, Xin Hu, Nickilou Y Krigbaum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Barbara A CohnChild Health and Development Studies, Public Health Institute, Berkeley, California, USA.ORCID https://orcid.org/0000-0002-9912-8447
Piera M CirilloChild Health and Development Studies, Public Health Institute, Berkeley, California, USA.
Michele A La MerrillDepartment of Environmental Toxicology, University of California, Davis, California, USA.
Caitlin C MurphyDepartment of Health Promotion & Behavioral Sciences, UTHealth Houston School of Public Health, Houston, Texas, USA.
Xin HuGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Nickilou Y KrigbaumChild Health and Development Studies, Public Health Institute, Berkeley, California, USA.

Funding

PEDIGREE: Prenatal Environmental Determinants of InterGenerational RiskU01ES019471 · NIEHS · PUBLIC HEALTH INSTITUTE · PI COHN, BARBARA A, TERRY, MARY BETH · 2010 to 2014
$1.9M
Prenatal Organochlorine Metabolites, Thyroid Function and DevelopmentR01ES017024 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FACTOR-LITVAK, PAM R · 2009 to 2010
$1.0M
In Utero Organochlorine Exposure & Breast DensityR01ES013736 · NIEHS · PUBLIC HEALTH INSTITUTE · PI COHN, BARBARA A · 2006 to 2009
$997k
Perinatal Exposure to Environmental DDT and Risk of Metabolic SyndromeR00ES019919 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LA MERRILL, MICHELE A · 2013 to 2015
$740k
California Breast Cancer Research 15ZB-0186California Breast Cancer Research 22UB-5411NICHD NIH HHS HHSN275201100020CNIEHS NIH HHS R00 ES019919NIEHS NIH HHS R01 ES013736NIEHS NIH HHS R01ES01376NIEHS NIH HHS R01 ES017024NIEHS NIH HHS R01ES017024NIEHS NIH HHS U01 ES019471
6 · The paper itself

Abstract

objectiveWe investigated in utero exposure to polychlorinated biphenyl (PCB) 138, PCB 153, and PCB 180 and obesity at reproductive age in a three-generation human cohort, i.e., the Child Health and Development Studies.

methodsWe used logistic models to estimate associations of PCBs in grandmothers' (F0) archived perinatal serum with obesity in daughters (F1) at age 30 years and granddaughters (F2) at age 26 years, accounting for family clustering (n = 258 triads). In order to reflect mixture exposures, we modeled PCBs as a ratio of the sum of PCB 138 + PCB 180 to PCB 153 (i.e., "PCB ratio").

resultsAn increase in the PCB ratio from the first to the third tertile corresponded to a 1.73 (95% CI: 1.06-2.82) increase in the odds of F1 obesity and a 1.96 (95% CI: 1.12-3.42) increase in the odds of F2 obesity. The association with F2 obesity differed by F0 BMI (p value for interaction = 0.08). F1 obesity was also associated with F2 obesity (odds ratio, 4.12, 95% CI: 1.95-8.72).

conclusionsGrandmothers' perinatal serum levels of mixtures of PCBs may have triggered a multigenerational cycle of obesity in daughters and granddaughters. Resultant obesity among women of reproductive age could further perpetuate obesity in subsequent generations.

Indexed as

Environmental PollutantsGrandparentsMaternal ExposureObesityPolychlorinated BiphenylsPrenatal Exposure Delayed EffectsAdultBody Mass IndexCohort StudiesFemaleHumansLogistic ModelsMaleNuclear FamilyPregnancyPrevalenceEnvironmental PollutantsPolychlorinated Biphenyls

Identifiers

PMID40275476
PMCPMC12119405

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.