Evidence map›Paper›PMID 40275438›Full record

ArticleNeurourology and urodynamics2025

Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN II) Urinary Urgency Phenotyping Study: Methods and Baseline Urinary Symptoms by Age and Sex.

Giulia M Ippolito, Kimberly Kenton, Catherine S Bradley, Ting Lu, Brian Bieber, J Quentin Clemens, Anna C Kirby, Ziya Kirkali, Magaly Guerrero, Claire C Yang and 9 more

Abstract read
In one paragraph

Article in Neurourology and urodynamics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giulia M IppolitoUniversity of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0002-6977-5280
Kimberly KentonUniversity of Chicago, Chicago, Illinois, USA.
Catherine S BradleyUniversity of Iowa, Iowa City, Iowa, USA.
Ting LuArbor Research, Ann Arbor, Michigan, USA.
Brian BieberArbor Research, Ann Arbor, Michigan, USA.
J Quentin ClemensUniversity of Michigan, Ann Arbor, Michigan, USA.
Anna C KirbyUniversity of Washington, Seattle, Washington, USA.
Ziya KirkaliNational Institute of Health NIDDK, Bethesda, Maryland, USA.
Magaly GuerreroDuke University, Durham, North Carolina, USA.
Claire C YangUniversity of Washington, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-4750-6258
Karl KrederUniversity of Iowa, Iowa City, Iowa, USA.
C Emi BretschneiderUniversity of Chicago, Chicago, Illinois, USA.
John GraffArbor Research, Ann Arbor, Michigan, USA.
Julia NashifArbor Research, Ann Arbor, Michigan, USA.
James W GriffithUniversity of Chicago, Chicago, Illinois, USA.
H Henry LaiWashington University, Seattle, Washington, USA.
Cindy L AmundsenDuke University, Durham, North Carolina, USA.
Anne P CameronUniversity of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0001-8414-3065
LURN Study Group

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating CenterU24DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI GRAFF, JOHN JOSEPH · 2019 to 2025
$6.9M
Phenotype of urinary symptoms and relationships with genotype, sleep and obesityU01DK097779 · NIDDK · UNIVERSITY OF CHICAGO · PI GRIFFITH, JAMES WILLIAM, KENTON, KIMBERLY SUE · 2012 to 2025
$5.7M
Advancing the Measurement and Classification of Lower Urinary Tract DysfunctionU01DK097780 · NIDDK · DUKE UNIVERSITY · PI AMUNDSEN, CINDY, JELOVSEK, JOHN ERIC · 2012 to 2025
$5.3M
University of Iowa LURN Research SiteU01DK097772 · NIDDK · UNIVERSITY OF IOWA · PI BRADLEY, CATHERINE S, KREDER, KARL J · 2012 to 2025
$5.0M
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)U01DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI MERION, ROBERT M · 2013 to 2018
$4.6M
University of Washington LURN Research SiteU01DK100011 · NIDDK · UNIVERSITY OF WASHINGTON · PI YANG, CLAIRE C · 2013 to 2025
$4.5M
University of Michigan LURN Research SiteU01DK099932 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN · 2013 to 2023
$4.4M
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Second Phase StudyU01DK100017 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2013 to 2025
$3.9M
University of Michigan UroEPI Career Development ProgramK12DK111011 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN, SARMA, ARUNA V · 2016 to 2025
$3.6M
NCATS NIH HHS UL1 TR001422NIDDK NIH HHS K12 DK111011NIDDK NIH HHS U01 DK097772NIDDK NIH HHS U01 DK097779NIDDK NIH HHS U01 DK097780NIDDK NIH HHS U01 DK099879NIDDK NIH HHS U01 DK099932NIDDK NIH HHS U01 DK100011NIDDK NIH HHS U01 DK100017NIDDK NIH HHS U24 DK099879This study is supported by the National Institute of Diabetes & Digestive & Kidney Diseases through cooperative agreements (grants DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, and DK099879). Research reported in this publication was supported at Northwestern University, in part, by the National Institutes of Health's National Center for Advancing Translational Sciences, Grant Number UL1TR001422.
6 · The paper itself

Abstract

aimsTo present the methods and baseline findings from a prospective, longitudinal cohort study of treatment seeking adults with urinary urgency (URG) with or without urgency urinary incontinence (UUI).

methodsAdults seeking treatment for URG and/or UUI and controls were enrolled. Participants completed physical examination, urine and serum studies, post-void residual, and validated questionnaires.

resultsData from 809 participants were analyzed. Cases and controls were both predominantly white. The mean overall age of the cases was older (62 vs. 59 years) as was the mean BMI and functional comorbidity index scores. Higher proportions of controls were never smokers. Among cases, bivariate analysis found higher proportions of women reporting URG, URG with fear of leaking, any UI and UUI. Men had higher proportions of often or almost always reporting nocturia. Higher proportions of men reported URG alone and UUI without stress UI. Mixed UI was prevalent among women but rare among men. In logistic regression models, women had higher odds of SUI, UUI, and dysuria compared to men. Men had higher odds of nocturia, intermittency, splitting/spraying, and hesitancy. Older participants had higher odds of UUI, nocturia, any UI, and URG with fear of leakage whereas younger participants had higher odds of stress UI, irritative symptoms.

conclusionTreatment-seeking adults with URG and/or UUI were older, had higher BMI, worse functional comorbidity index and higher proportions of prior smoking history compared to controls. Among cases, sex and age differences were seen in within the spectrum of URG and UUI.

Indexed as

Lower Urinary Tract SymptomsUrinary Incontinence, UrgeAdultAgedAge FactorsCase-Control StudiesFemaleHumansLogistic ModelsLongitudinal StudiesMaleMiddle AgedNocturiaPhenotypePrevalenceProspective Studiesepidemiologylower urinary tract symptomsnocturiaurgency urinary incontinenceurinary urgency

Identifiers

PMID40275438
PMCPMC12164244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.