Evidence map›Paper›PMID 40275325›Full record

ArticleCell communication and signaling : CCS2025

CTSL-2 upon specifically recognizing Vibrio splendidus directly cleaves complement C3 to promote the bacterial phagocytosis and degradation in oyster.

Qiuyan Guo, Wenwen Yang, Weishuai Shan, Hongsheng Yao, Xiangqi Shi, Lingling Wang, Jiejie Sun, Linsheng Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. C3 inFrontiers in cellular and infection microbiology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiuyan GuoLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, 52 Heishijiao Street, Dalian, 116023, China.
Wenwen YangLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, 52 Heishijiao Street, Dalian, 116023, China.
Weishuai ShanLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, 52 Heishijiao Street, Dalian, 116023, China.
Hongsheng YaoLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, 52 Heishijiao Street, Dalian, 116023, China.
Xiangqi ShiLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, 52 Heishijiao Street, Dalian, 116023, China.
Lingling WangLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, 52 Heishijiao Street, Dalian, 116023, China.
Jiejie SunLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, 52 Heishijiao Street, Dalian, 116023, China. sunjiejie@dlou.edu.cn.
Linsheng SongLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, 52 Heishijiao Street, Dalian, 116023, China. lshsong@dlou.edu.cn.

Funding

Dalian High Level Talent Innovation Support Program 2022RG14Dalian Outstanding Young Scientific and Technological Talent 2022RY01Liaoning Revitalization Talents Program XLYC2203087National Science Foundation of China 32222086the innovation team of Aquaculture Environment Safety from Liaoning Province LT202009
6 · The paper itself

Abstract

Cathepsin L (CTSL) as a cysteine cathepsin protease mediates complement C3 cleavage and pathogen degradation. In the present study, a CTSL homolog was identified from Crassostrea gigas (designated as CgCTSL-2). Its mRNA expression increased significantly in hemocytes after Vibrio splendidus stimulation. The activity of rCgCTSL-2 was induced after incubation with LPS or V. splendidus in Ca

Indexed as

Cathepsin LComplement C3CrassostreaOstreidaePhagocytosisVibrioAmino Acid SequenceAnimalsHemocytesHemolymphProteolysisCathepsin LComplement C3Cathepsin LCD18Complement C3PhagocytosisVibrio splendidus

Identifiers

PMID40275325
PMCPMC12023428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.