Evidence map›Paper›PMID 40275305›Full record

Observational studyScandinavian journal of trauma, resuscitation and emergency medicine2025

Utility of point of care viscoelastic haemostatic assays for trauma patients in the emergency department.

Andrew Richard Coggins, Vinh Dat David Nguyen, Leonardo Pasalic, Murari Ramesh, Kush Wangoo

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scandinavian journal of trauma, resuscitation and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Initial TEG 6s parameters for risk stratification of hemorrhage-related outcomes in massively transfused trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  2. Early transfusion strategies in haemorrhagic shock.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew Richard CogginsDepartment of Emergency Medicine, Westmead Hospital, Hawkesbury Road, Sydney, NSW, 2145, Australia. andrew.coggins@health.nsw.gov.au.ORCID http://orcid.org/0000-0002-5652-6920
Vinh Dat David NguyenWestern Sydney Local Health DistrictWestmead Hospital, Hawkesbury Road, Sydney, NSW, 2145, Australia.
Leonardo PasalicDepartment of Haematology, Westmead Hospital, Hawkesbury Road, Sydney, NSW, 2145, Australia.ORCID http://orcid.org/0000-0002-8237-6743
Murari RameshWestern Sydney Local Health DistrictWestmead Hospital, Hawkesbury Road, Sydney, NSW, 2145, Australia.ORCID http://orcid.org/0000-0002-3049-6786
Kush WangooWestern Sydney Local Health DistrictWestmead Hospital, Hawkesbury Road, Sydney, NSW, 2145, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTraumatic haemorrhage often requires initiation of a massive haemorrhage protocol (MHP). The primary aim of this exploratory Emergency Department (ED) study was to examine the utility of point of care Viscoelastic Haemostatic Assays (VHA) in terms of accuracy. The primary outcome was prediction of the need for massive transfusion (MT) at 24-hours.

methodsProspective observational study of consecutive trauma patients investigated with reported using STARD guidelines. Patients in an Australian ED setting < 1-hour from triage enrolled in a three-year window. The point-of-care device used was a TEG6s™ (Haemonetics, Braintree, MA, USA). The primary outcome was accuracy VHA testing for predicting MT delivery at 24-hours (an internationally recognised of massive transfusion was used). Other trauma outcomes such as product transfusion, injury severity score (ISS) and demographics were recorded. For analysis of accuracy the cohort was divided into VHA-normal (n = 44) and VHA-abnormal (n = 70) binary groups. Secondary outcomes included utility of TEG6s™ individual components and accuracy of VHA when combined with validated MHP decision scores.

resultsAmong eligible cases (n = 114) in-patient mortality was 7.0% with 91.2% receiving transfusion. Presence of (any) abnormal VHA result provided a 73.6% (95%CI 59.7-84.7) sensitivity and 49.3% (95%CI 36.1-62.3) specificity for predicting MT. Citrated Functional Fibrinogen (CFF) component had a higher performance for MT "rule-in" specificity (86.9%). When VHA was combined with validated MHP decision scores performance was increased. For example, normal VHA with Trauma Associated Severe Haemorrhage score < 8.5 was observed to yield a sensitivity of 96.2% for MT requirement rule-out. Further studies should examine if VHA test parameters can be added or (replace INR) in the existing clinical scores used to make decisions about transfusion in ED patients.

conclusionThe standalone performance of early VHA testing in the ED setting was insufficient to reliably for predict a need for massive transfusion.

Indexed as

Emergency Service, HospitalHemorrhagePoint-of-Care SystemsThrombelastographyWounds and InjuriesAdultAgedAustraliaBlood TransfusionFemaleHumansInjury Severity ScoreMaleMiddle AgedProspective StudiesTriageAccident & emergency medicineBlood bank & transfusion medicineTrauma management

Identifiers

PMID40275305
PMCPMC12023681

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.