Evidence map›Paper›PMID 40275290›Full record

ArticleJournal of translational medicine2025

Evidence supporting the role of hypertension in the onset of migraine.

Guoqiang Xiao, Zitong Huang, Qiaoyu Lan, Jiajia Hu, Hongting Shi, Yongyuan Chen, Chumeng Zhou, Lin Chenghua, Borong Zhou

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In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guoqiang XiaoDepartment of Psychiatry and Psychology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetries and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Zitong HuangDepartment of Psychiatry and Psychology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetries and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Qiaoyu LanDepartment of Neurology, Liwan Central Hospital, Guangzhou, Guangdong, China.
Jiajia HuDepartment of Psychiatry and Psychology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetries and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Hongting ShiDepartment of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yongyuan ChenDepartment of Neurology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chumeng ZhouMedical Administration College, Guangzhou Medical University, Guangzhou, Guangdong, China.
Lin ChenghuaMedical Administration College, Guangzhou Medical University, Guangzhou, Guangdong, China.
Borong ZhouDepartment of Psychiatry and Psychology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetries and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. zhoubr8@aliyun.com.ORCID 0000-0002-5985-8998

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between hypertension and migraine remains unclear.

objectiveThe aim of this study employ multi-layered evidence chain that revealed the association between hypertension and migraine.

methodsWe first strictly included data from the NHANES 1999-2004 population and applied logistic regression, subgroup analysis and RCS to assess the correlation between hypertension, SBP, DBP and migraine. Meanwhile, LDSC and Mendelian randomization were conducted based on the GWAS to determine the causal relationship between hypertension and migraine. Inverse-variance weighted (IVW) was used as the primary method. Sensitivity analysis and Colocalization analysis were performed to confirm the robustness of the results. LDSC validated the genetic correlation between traits. Enrichment analysis revealed their underlying biological mechanisms.

resultsAfter strict inclusion in NHANES, 10,743 participants were included. The logistic regression showed a significant correlation between hypertension (OR = 1.21 [95% CI, 1.08-1.36], FDR < 0.001)、DBP (OR = 1.01 [95% CI, 1.01-1.02], FDR < 0.001) and migraine. This association did not show significant group differences in subgroup. The MR results further supported the existence of a significant causal relationship between hypertension (OR = 1.77 [95% CI, 1.43-2.30], FDR < 0.001)、DBP (OR = 1.02 [95% CI, 1.01-1.03], FDR < 0.001) and migraine onset. Additionally, the RCS analysis showed a linear relationship (P non-linear = 0.897) between the two. The LDSC result showed a significant genetic correlation between the two (Rg = 0.1092, SE = 0.028, P < 0.001).

conclusionThe development of migraine caused by hypertension is mainly realized through high DBP.

Indexed as

HypertensionMigraine DisordersAdultBlood PressureFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLogistic ModelsMaleMendelian Randomization AnalysisMiddle AgedNutrition SurveysDiastolic blood pressureHypertensionMigraineMRNHANES

Identifiers

PMID40275290
PMCPMC12023583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.