Evidence map›Paper›PMID 40275275›Full record

ArticleBMC oral health2025

Surgical extraction with photobiomodulation as an adjunctive modality in patients at-risk for medication-related osteonecrosis of the jaw: retrospective study.

Gianluca Tenore, Ahmed Mohsen, Alessandro Del Vecchio, Gaspare Palaia, Federica Rocchetti, Lucia Borghetti, Giuseppe Vasile, Francesca Graniero, Umberto Romeo

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In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gianluca TenoreDepartment of Oral and Maxillofacial Sciences (SOMF), Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Ahmed MohsenDepartment of Oral and Maxillofacial Sciences (SOMF), Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy. ahmed.mohsen@uniroma1.it.
Alessandro Del VecchioDepartment of Oral and Maxillofacial Sciences (SOMF), Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Gaspare PalaiaDepartment of Oral and Maxillofacial Sciences (SOMF), Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Federica RocchettiDepartment of Oral and Maxillofacial Sciences (SOMF), Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Lucia BorghettiDepartment of Oral and Maxillofacial Sciences (SOMF), Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Giuseppe VasileDepartment of Oral and Maxillofacial Sciences (SOMF), Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Francesca GranieroDepartment of Oral and Maxillofacial Sciences (SOMF), Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Umberto RomeoDepartment of Oral and Maxillofacial Sciences (SOMF), Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe study aims to retrospectively assess and share the experience of the use of photobiomodulation (PBM) as an adjunctive to surgical extraction in patients at-risk for medication-related osteonecrosis of the jaw (MRONJ) due to a treatment history with bone-modifying agents.

methodsThe department database and medical records were examined in the period between 2016 and 2023. The inclusion criteria were; at-risk patients for MRONJ with current or previous treatment with bone-modifying agents, with or without a history of antiangiogenic agents administration, who underwent single or multiple dental extractions, subjected to PBM preventive protocol, and without a diagnosis or history of MRONJ development. The PBM protocol consisted of four sessions, two sessions before the intervention and two sessions after the intervention. The PBM parameters (per session) were; total power of 0.6 W, time of 15 min, frequency of 30 kHz, and total energy of 577.4 J.

resultsA total of 62 patients (58 females and 4 males) fulfilled the inclusion criteria with a mean age of 67.5 years. Complete healing without the development of MRONJ was shown in 50 (80.65%) patients, and the development of MRONJ was shown in 12 (19.35%) patients. The statistical analysis revealed a higher risk of MRONJ in patients with a history of administration of zoledronic acid (p = 0.029) and in patients undergoing corticosteroid therapy (p = 0.039). While a lower risk was observed in patients in treatment for thyroid pathology (p = 0.055).

conclusionsThe majority of the included at-risk MRONJ patients showed complete healing after surgical extraction with the use of PBM as an adjunctive modality. Corticosteroid treatment as a systemic risk factor and zoledronic acid as a drug-related risk factor show significant associations with the development of MRONJ.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawLow-Level Light TherapyTooth ExtractionAgedAged, 80 and overBone Density Conservation AgentsCombined Modality TherapyFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsZoledronic AcidBone Density Conservation AgentsZoledronic AcidDiode laserMedication-related osteonecrosis of the jawOsteonecrosisPhotobiomodulationSurgical extraction

Identifiers

PMID40275275
PMCPMC12023369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.