ArticleJournal of translational medicine2025
Impacts of air pollutions on cardiovascular and cerebrovascular diseases through inflammation: a comprehensive analysis of one million Chinese and half million UK individuals.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Predicting Daily Cardiovascular Emergencies Using Weather and Air Quality Data: A 23-Year Machine-Learning Analysis in Taiwan.GeoHealth · 2026Article
- Article
- Air Pollution Monitoring with Nanoscaled Materials in Chemoresistive Gas Sensors.ACS applied materials & interfaces · 2026Review
- Evaluation of the relationship between Air Health Index and the risk of cardiovascular and cerebrovascular disease mortality in Huizhou City: a cross-sectional study.BMJ public health · 2026Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
backgroundEpidemiological studies have found an association between air pollution and cardiovascular and cerebrovascular diseases (CACD) and its subtypes. However, there is a lack of individual-level data to explore the associations of air pollutants on CACD and its subtypes, the interaction among them, and the potential mechanism.
methodsThis study employed a two-stage design, combining a time-stratified case-crossover study with a cohort study, analyzing data from one million individuals from China and half million from the UK. The study assessed the impact of air pollutants on CACD and its subtypes, while also examining the mediating effects of inflammation. Distributed lag non-linear models were used to analyze the lagged effects of pollutants, and mediation analysis was conducted to evaluate the role of inflammatory markers (SII, SIRI, AISI) in the relationship between air pollution and CACD.
resultsA total of 829,135 CSDs patients were recorded in this study. An interquartile range (IQR) increase in concentrations of PM
conclusionsThis study provides robust evidence that short-term exposure to common air pollutants significantly increases the risk of CACD and its subtypes, with inflammation playing a crucial mediating role. The findings underscore the importance of coordinated air pollution control strategies and public health interventions to mitigate the cardiovascular risks associated with air pollution.
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