ArticleBMC biotechnology2025
Electrospun PCL membranes for localized drug delivery and bone regeneration.
Article in BMC biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Design and applications of barrier membranes for guided bone regeneration.Bioactive materials · 2026Review
- Reconstructing the Periosteal Niche with Regenerated Cellulose Nanofibers for Endogenous Bone Regeneration.Journal of functional biomaterials · 2026Article
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- Mineral-Botanical Hybrid Nanofibrous Dressing for Post-Surgical Melanoma Wound Healing.Polymers · 2026Article
- Research interests and trends in alveolar ridge augmentation and visualization of articles from 1990 to 2024: a bibliometric analysis.The Saudi dental journal · 2026Article
- Advanced Antibacterial Nanocomposite Fibers for Biomedical Applications.Pharmaceutics · 2026Article
- Cotton-Type Nanofiber Guided Pathway Engineering Enables Rapid Tissue Integration and Accelerated Bone Regeneration in Mineral Powder-Based Bone Grafts.Journal of functional biomaterials · 2026Article
- In situ synthesized Van-ZIF-8 functionalized electrospun PCL membrane with pH-responsive dual functionality for oral guided bone regeneration.Journal of materials science. Materials in medicine · 2026Article
- Optimizing Alveolar Ridge Preservation and GBR: A Systematic Review of Membranes, Grafts, and Soft Tissue Strategies for Personalized Care.International journal of dentistry · 2026Review
- Article
- Advanced Biocompatible and Biodegradable Polymers: A Review of Functionalization, Smart Systems, and Sustainable Applications.Polymers · 2025Review
- Modeling and Design of Chitosan-PCL Bi-Layered Microspheres for Intravitreal Controlled Release.Pharmaceutics · 2025Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone loss caused by cysts, tumors, trauma, and other factors is a significant challenge in medicine and dentistry. Effective bone regeneration is essential for accelerated healing and improved bone volume. While systemic drug supplementation helps, local delivery through gbr/gtr membranes is preferred for targeted treatment with minimal systemic effects. This study aims to develop drug-loaded gbr membranes using electrospinning to enhance localized drug delivery and tissue regeneration.
methodsPolycaprolactone (PCL) membranes were produced via electrospinning with various concentrations and solvent ratios. Therapeutic agents-pentoxifylline, carrageenan, and sodium fluoride-were incorporated into the membranes. Morphological analysis was performed using scanning electron microscopy (SEM), mechanical properties were assessed through tensile testing, structural characterization was done via Fourier-transform infrared spectroscopy (FTIR), and thermal properties were evaluated with thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Drug release behavior was studied using UV-Vis spectrophotometry.
resultsSEM revealed optimal fiber morphology in membranes with 10% PCL and 1% pentoxifylline, 0.5% NaF, and 1% carrageenan. Tensile strength was highest in 10% PCL membranes (2.5 MPa), outperforming 12% PCL (1.8 MPa). FTIR and TGA confirmed successful drug incorporation and thermal stability, with decomposition temperatures ranging from 395 °C to 510.9 °C. UV-Vis showed effective drug release, with 2% pentoxifylline achieving the highest release at 2 h (34%) and 4 h (62%), demonstrating enhanced performance for localized drug delivery.
conclusionsPCL-based electrospun membranes with therapeutic agents were successfully developed, exhibiting promising characteristics for localized drug delivery and tissue regeneration. These membranes showed comparable mechanical properties to commercial GBR/GTR membranes. Future research should focus on optimizing formulations and evaluating clinical efficacy.
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