ArticleBMC cardiovascular disorders2025
Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003-2017.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Genetic and epidemiological insights into the role of neutrophil percentage in heart failure risk: a Mendelian randomization and NHANES study.Molecular and cellular biochemistry · 2026Article
- Preoperative Inflammatory Burden Index Predicts Atrial Fibrillation After Coronary Artery Bypass Grafting: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Association of the inflammatory burden index with 1-year major adverse cardiovascular events in patients with HFpEF after myocardial infarction: a single-center retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Predictive Value of Inflammatory Burden Index for Sepsis in Critically Ill Patients with Extensive Burns: A Decade-Long Cohort Study.Journal of inflammation research · 2026Article
- Association between the inflammatory burden index and erectile dysfunction: a cross-sectional study based on NHANES 2001-2004.Journal of health, population, and nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSystemic inflammation contributes to the progression of heart failure (HF). This study aims to investigate the association between inflammatory burden index (IBI) and HF risk.
methodsIn this cross-sectional study of NHANES 2003-2017, data from 19,856 participants were analyzed, including 652 participants with HF and 19,204 without HF. Participants were categorized into quartiles based on IBI levels (Q1-Q4). The risk of HF across these quartiles was assessed with adjustment for potential confounders and restricted cubic spline analyses were used to evaluate dose-response relationships.
resultsOur results show that participants with HF have higher IBI levels compared to those without HF (2.66 ± 0.27 vs. 1.05 ± 0.03, p < 0.001). The prevalence of HF increases with higher IBI quartiles: Quartile 1 (1.2%), Quartile 2 (1.33%), Quartile 3 (2.60%), and Quartile 4 (4.37%) (p < 0.001). After adjusting for potential confounders, the risk of HF remained elevated across the quartiles: Quartile 2 (odds ratio [OR] = 0.72, 95% confidence interval [CI]: 0.48-1.10), Quartile 3 (OR = 1.06, 95% CI: 0.70-1.61), and Quartile 4 (OR = 1.46, 95% CI: 1.02-2.10) compared to Quartile 1. Restricted cubic spline analysis further confirmed a substantial positive-linear correlation between IBI and HF risk.
conclusionHigher levels of IBI are related to a high risk of HF, independent of traditional risk factors. These results suggest that IBI could be a useful parameter for identifying individuals at higher risk of HF. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.