ArticleBMC genomics2025
CircRNA profiling reveals circSMC1B that promotes bovine male germline stem cells proliferation and apoptosis via sponging let-7i.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The sperm survival switch: circRNA-mediated regulatory loops control apoptotic signalling in human spermatozoa.Cell death discovery · 2026Article
- Circular RNAs in osteosarcoma: mechanistic insights, autophagy regulation, and potential therapeutic strategies.Cancer cell international · 2026Review
- Novel circNSD2 promotes proliferation and testosterone synthesis while inhibiting apoptosis in bovine Leydig cells.Frontiers in veterinary science · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundDespite significant advancements in artificial insemination techniques, male reproduction continues to pose a considerable challenge in cattle breeding. Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), play a crucial role in regulating testis growth and spermatogenesis. Therefore, it is essential to comprehend the involvement of circRNAs in bull reproduction for livestock production. However, the identification of differentially expressed circRNAs during testis development and their underlying mechanisms remains largely unknown.
resultsIn this study, RNA-seq was employed to investigate the expression of circRNAs in neonatal and sexually mature bovine testes. We identified 28,065 candidate circRNAs, of which 987 circRNAs showed differential expression between the two stages (P-adjust < 0.05). Notably, circSMC1B was significantly up-regulated in sexually mature testis. Overexpression of circSMC1B promoted the proliferation and apoptosis of bovine male germline stem cells (mGSCs). Further analysis revealed that circSMC1B acts as a molecular sponge for let-7i, while High mobility group AT-hook 1/Nuclear receptor subfamily 6 group A member 1 (HMGA1/NR6 A1) were identified as direct targets of let-7i. Furthermore, circSMC1B levels exhibited a significant positive correlation with HMGA1/NR6A1 mRNA expression in bovine mGSCs, highlighting the critical role of competing endogenous RNA (ceRNA) mechanisms.
conclusionOur research elucidates that circSMC1B, through let-7i binding, promotes bovine mGSCs proliferation and apoptosis by targeting HMGA1/NR6A1. These findings provide valuable resources for studying the functional aspects of circRNAs in testis development and enhance our understanding of the biological function of circSMC1B in promoting bull spermatogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.