ArticleScientific reports2025
Optimizing feasibility and reproducibility of pacing-induced heart failure model in pigs.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Translational Strategies for Developing and Evaluating Transcatheter Devices in Swine Heart Failure Models.Annals of biomedical engineering · 2026Review
- Gene Therapy for Heart Failure.Journal of cardiovascular translational research · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure (HF) is a major health problem worldwide, where gene therapy could provide promising new approaches for effective treatments. Pacing-induced tachycardiomyopathy in large animals is a well-established HF model but it suffers from poor tolerability and variable outcomes. In this study, we developed a reproducible, feasible, and tolerable pacing protocol for HF gene therapy studies. Single-chamber pacemakers were implanted in pigs. HF development was monitored with trans-thoracic echocardiography (TTE), invasive left-ventricular (LV) pressure measurements, and a treadmill exercise stress test. Four weeks of rapid right-ventricular pacing at over 200 bpm produced a significant impairment of cardiac function (LV stroke volume index 11.8 ± 1.22 (mL/m
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