Evidence map›Paper›PMID 40274983›Full record

ArticleScientific reports2025

Glycyrrhiza uralensis crude water extract and licochalcone A and B to enhance chicken muscle satellite cell differentiation for cultured meat production.

Eun Ju Lee, Sibhghatulla Shaikh, Jin Hee Lee, Sun Jin Hur, Inho Choi

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eun Ju Lee *Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, South Korea.
Sibhghatulla Shaikh *Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, South Korea.
Jin Hee LeeDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, South Korea.
Sun Jin HurDepartment of Animal Science and Technology, Chung-Ang University, Anseong, 17546, South Korea.
Inho ChoiDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, South Korea. inhochoi@ynu.ac.kr.

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF) 2020R1A6A1A03044512Forestry (IPET) through High Value added Food Technology Development Program of the Korea Institute of Planning and Evaluation for Technology in Food and Agriculture funded by the Ministry of Agriculture, Food, and Rural Affairs (MAFRA) 321026-05National Research Foundation of Korea (NRF) grant funded by the Korean government NRF-2021R1A2C2004177
6 · The paper itself

Abstract

Muscle satellite cells (MSCs) are the most commonly used cells in cultured meat research and development. Enhancing MSC proliferation and differentiation while reducing cell culture costs is requisite to commercializing cultured meat. This study explored the effects of Glycyrrhiza uralensis crude water extract (GU-CWE) and licochalcone A and B (Lic A or B) on the proliferation and differentiation of chicken, bovine, and porcine MSCs. While GU-CWE and Lic A and B had negligible effects on bovine and porcine MSCs, GU-CWE significantly enhanced chicken MSC differentiation, and Lic A and B promoted both the proliferation and differentiation of chicken MSCs. Furthermore, GU-CWE was found to mitigate reactive oxygen species activity during chicken MSC differentiation and promote cell proliferation and adhesion in spheroid culture, thereby maintaining a spherical shape. Collectively, this study suggests that GU-CWE and Lic A and B can significantly reduce costs and safely increase the productivity of chicken MSCs in cultured meat production processes.

Indexed as

Cell DifferentiationChalconesGlycyrrhiza uralensisMeatPlant ExtractsSatellite Cells, Skeletal MuscleAnimalsCattleCell ProliferationCells, CulturedChickensIn Vitro MeatReactive Oxygen SpeciesSwineWaterChalconeslicochalcone APlant ExtractsReactive Oxygen SpeciesWaterCultured meatDifferentiationGlycyrrhiza uralensisMuscle satellite cellsProliferation

Identifiers

PMID40274983
PMCPMC12022269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.