Trial reportScientific reports2025
Cognitive and neurophysiological effects of bilateral tDCS neuromodulation in patients with minimally conscious state.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- P300 Event-Related Potentials as Cognitive Biomarkers in Neurological and Neuropsychiatric Disorders: A Systematic Review.Revista de neurologia · 2026Pooled it
- Non-invasive neuroregulation techniques applied to patients with consciousness disorders: a narrative review.Frontiers in human neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The minimally conscious state (MCS) is a clinical condition characterized by severely reduced but present awareness of self and the environment. Transcranial direct current stimulation (tDCS) has shown promising potential. The aim of this quasi-randomised control study was to investigate the effects of bilateral of tDCS applied to the right and left dorsolateral prefrontal cortex (DLPFC) on neurophysiological and cognitive outcomes in 28 patients with MCS. Participants were quasi-randomly assigned to one of two groups: experimental group with tDCS over both DLPFC, and a control group, which received sham tDCS. Neurophysiological assessments included event-related potentials (ERPs) analysis (N200 and P300) and EEG beta band study. Clinical outcomes were measured using ad hoc psychometric battery, including Coma Recovery Scale-Revised (CRS-R), Levels of Cognitive Functioning Scale (LCFS), and Functional Independence Measure (FIM). The findings revealed a significant improvement in ERP latencies and increased beta band rhythms in the experimental group, indicating enhanced neural responsiveness to cognitive stimuli. Additionally, significant improvements were observed in clinical measures of awareness and functional capacity. These findings suggest that tDCS may represent a promising therapeutic option for enhancing both neurophysiological responses and cognitive functioning in patients with MCS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.