Evidence map›Paper›PMID 40274935›Full record

ArticleNpj mental health research2025

Impaired mnemonic pattern separation associated with PTSD symptoms paradoxically improves with regular cannabis use.

Jacob Ross, Bruna Cuccurazzu, Dylan Delmar, Christian Cortez, Giovanni Castillo, Dean T Acheson, Dewleen G Baker, Victoria B Risbrough, Daniel M Stout

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj mental health research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacob RossDepartment of Biological Sciences, University of California San Diego, San Diego, CA, USA. jdross@health.ucsd.edu.
Bruna CuccurazzuDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Dylan DelmarDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Christian CortezDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Giovanni CastilloDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Dean T AchesonDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Dewleen G BakerDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Victoria B RisbroughDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Daniel M StoutDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2013 to 2023
$25.4M
BLRD VA IK6 BX006186CSRD VA IK2 CX001861NIMH NIH HHS P50 MH096889NIMH NIH HHS P50MH096889U.S. Department of Veterans Affairs IK2-CX001861Wellcome Trust 059392
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) is associated with poor hippocampal function and disrupted pattern recognition. Cannabis use is highly prevalent in individuals with PTSD, yet the impact on these cognitive functions is poorly understood. Participants (n = 111) with a range of PTSD symptoms with and without regular cannabis use completed the mnemonic similarity task. We hypothesized that regular use would be associated with alterations in pattern separation ability in individuals with PTSD symptoms. High PTSD symptoms were associated with reduced pattern separation performance in minimal users. Regular users with high PTSD symptoms showed greater pattern separation, but reduced pattern separation with low PTSD symptoms. These results suggest that regular cannabis use may disrupt pattern separation and similar hippocampal-dependent processes, while it may improve pattern separation in individuals with high PTSD symptoms. These cross-sectional results require longitudinal follow-up studies to evaluate the causal effects of regular cannabis use on cognitive function in PTSD.

Identifiers

PMID40274935
PMCPMC12022266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.