Evidence map›Paper›PMID 40274909›Full record

ArticleScientific reports2025

Hemosiderin quantification in hemophilic arthropathy using quantitative magnetic resonance imaging.

Sam Sedaghat, Jame V Luck, Annette von Drygalski, Eddie Fu, Jin Il Park, Kim Gina Gehling, Yajun Ma, Scott Ball, Eric Y Chang, Jiang Du and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sam SedaghatDepartment of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Jame V LuckDepartment of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
Annette von DrygalskiDepartment of Medicine, University of California, San Diego, San Diego, CA, USA.
Eddie FuDepartment of Radiology, University of California, Davis, Sacramento, CA, USA.
Jin Il ParkDepartment of Radiology, University of California, Davis, Sacramento, CA, USA.
Kim Gina GehlingDepartment of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Yajun MaDepartment of Radiology, University of California, San Diego, San Diego, CA, USA.
Scott BallDepartment of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, USA.
Eric Y ChangDepartment of Radiology, University of California, San Diego, San Diego, CA, USA.
Jiang DuDepartment of Radiology, University of California, San Diego, San Diego, CA, USA.
Hyungseok JangDepartment of Radiology, University of California, Davis, Sacramento, CA, USA. hyjang@ucdavis.edu.

Funding

Ultrashort Echo Time Magnetic Resonance Imaging of Hemophilic ArthropathyR01AR078877 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JANG, HYUNGSEOK · 2021 to 2025
$2.4M
Three-dimensional Ultrashort Echo Time Magnetic Resonance Imaging of EnthesesR01AR075825 · NIAMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI CHANG, ERIC Y · 2019 to 2023
$1.8M
CSRD VA I01 CX001388DFG SE 3272/1-1NIAMS NIH HHS R01 AR078877NIH HHS R01AR075825NIH HHS R01AR078877VA Clinical Science Research and Development Services I01CX001388
6 · The paper itself

Abstract

The goal of this study is to quantify hemosiderin deposition in the knee joint tissues of hemophilic arthropathy (HA) patients using quantitative susceptibility mapping on MRI. Knee synovial tissues from HA patients and controls without hemophilia were included. The tissues underwent ultrashort echo time quantitative susceptibility mapping (UTE-QSM) and clinical MRI. HA tissues were processed histologically with Perl's Prussian Blue (PPB) staining to identify iron contents. Seven regions of interest were drawn in each tissue, and the susceptibility values were tested. Moreover, the association between the estimated magnetic susceptibility and the iron contents quantified by histology was investigated. Nine synovial tissues were procured from total knee arthroplasty of hemophilia patients (males, 40.8 ± 9.0 years), and three synovial tissues were harvested from cadaveric knee joints of donors without hemophilia as controls (males, 72.0 ± 12.8 years). The estimated susceptibility values (ESVs) showed significant differences between HA and control samples. Accordingly, HA tissues presented a mean ESV of 0.48 ± 1.08 ppm and control tissues of -0.13 ± 0.12 ppm (p < 0.05). A significant linear correlation was found between the iron level quantified by histology (PPB stain) and the ESV estimated by UTE-QSM (R = 0.908, p < 0.01). There was a significant difference in the susceptibility in high load (HL) tissues compared to low load (LL) tissues (ESV = 5.57 ± 1.23 ppm for HL vs. 0.57 ± 0.85 ppm for LL, p < 0.001). Reliable hemosiderin quantification in joint tissues of HA patients can be achieved using MRI based on quantitative susceptibility mapping.

Indexed as

HemarthrosisHemophilia AHemosiderinKnee JointMagnetic Resonance ImagingAdultAgedCase-Control StudiesFemaleHumansIronMaleMiddle AgedSynovial MembraneHemosiderinIronHemophiliaHemophilic arthropathyHemosiderinMRIQuantitative susceptibility mapping

Identifiers

PMID40274909
PMCPMC12022072

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.