Evidence map›Paper›PMID 40274845›Full record

ArticleNature communications2025

GHS-R1a signaling drives anxiety-related behavior by shaping excitability of ventromedial hypothalamic neurons.

Meng Zhang, Liu Yang, Xue Mi, Gonghui Hu, Yingchang Lu, Chen Wang, Jie Yang, Xiaomin Sun, Minglu Niu, Xianchao Li and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Meng ZhangSchool of Life Sciences and Health, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266113, China.ORCID http://orcid.org/0009-0004-0684-472X
Liu YangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Xue MiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Gonghui HuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Yingchang LuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Chen WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Jie YangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Xiaomin SunDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Minglu NiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Xianchao LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Sihan WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Jingsai ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Hanbing YuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Yuyang WangDepartment of Rehabilitation Medicine, Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China.
Ming YuSchool of Life Sciences and Health, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266113, China.
Nan LiSchool of Life Sciences and Health, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266113, China.ORCID http://orcid.org/0000-0002-5828-6975
Yu ZhouSchool of Life Sciences and Health, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266113, China. yuzhou@uhrs.edu.cn.ORCID http://orcid.org/0000-0002-8193-7561

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32071141National Natural Science Foundation of China (National Science Foundation of China) 32371211National Natural Science Foundation of China (National Science Foundation of China) 91732110Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2019ZD34
6 · The paper itself

Abstract

The neural substrates of anxiety are poorly understood, which hinders treatment of anxiety disorders. Here we found, αCaMKII

Indexed as

AnxietyNeuronsReceptors, GhrelinVentromedial Hypothalamic NucleusAnimalsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 2MaleMiceMice, Inbred C57BLRestraint, PhysicalSignal TransductionStress, PsychologicalCalcium-Calmodulin-Dependent Protein Kinase Type 2Ghsr protein, MouseReceptors, Ghrelin

Identifiers

PMID40274845
PMCPMC12022087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.