ArticleScientific reports2025
Competitive enzyme linked aptamer based assay for salivary melatonin detection.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Melatonin is a key hormone that regulates the sleep-wake cycle and plays an important role in maintaining circadian rhythm and sleep onset. The daily rise in melatonin secretion is associated with an increased tendency to sleep, occurring approximately 2 h before bedtime. This correlation between melatonin levels and sleep onset makes it a reliable biomarker for circadian rhythm sleep-wake disorders. An accurate assessment of dim light melatonin onset (DLMO) is vital for understanding circadian timing and diagnosing sleep-wake cycle disruptions. However, the traditional methods for detecting melatonin in saliva are either complex or lack the sensitivity required for the accurate assessment of DLMO, especially at low concentrations. Here, we present a novel competitive enzyme-linked aptamer-based assay developed to detect melatonin in saliva. Unlike conventional assays, this technique utilizes chemically synthesized single-stranded DNA or RNA aptamers, which bind to melatonin with high specificity and sensitivity. The assay measures melatonin, attaining a linear dynamic range from 8.62 × 10
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