Evidence map›Paper›PMID 40274838›Full record

ArticleScientific reports2025

Burden of multi-drug resistant bacterial isolates and its associated risk factors among UTI-confirmed geriatrics in Gondar town.

Getachew Bitew, Mulat Dagnew, Mahliet Dereje, Abebe Birhanu, Yalewayker Gashaw, Aklilu Ambachew, Belay Tessema

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Getachew BitewDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. gtwbtw4550@gmail.com.ORCID http://orcid.org/0009-0009-6079-0271
Mulat DagnewDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Mahliet DerejeMicrobiology Laboratory, University of Gondar Comprehensive Specialized Hospital, Gondar, Ethiopia.
Abebe BirhanuDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.ORCID http://orcid.org/0009-0005-0363-3254
Yalewayker GashawDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia.
Aklilu AmbachewDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Belay TessemaDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multi-drug resistant (MDR) bacterial urinary tract infection (UTI) is a significant health threat in the geriatric population, with limited data in this study area. Therefore, this study aimed to assess the burden of MDR bacterial isolates and associated risk factors among UTI-confirmed geriatrics in Gondar, providing essential information for geriatric patients, healthcare workers, scientists, and policymakers to guide antibiotic stewardship interventions. A prospective cross-sectional study was conducted among 204 UTI-confirmed geriatrics. Socio-demographic data were collected via a structured questionnaire, and bacterial identification and drug resistance testing followed standard microbiological techniques. Data were entered using Epi Data version 4.0.0 and analyzed by Stata/IC version 14.0, with bivariate and multivariate logistic regressions to identify risk factors. A P-value < 0.05 was considered statistically significant. The overall prevalence of MDR UTI-confirmed geriatrics and MDR bacterial isolates were 115 (56.4%) and 126 (49.6%), respectively. The MDR Gram-negative isolates accounted for 105 (83.3%), and Gram-positive isolates 21 (16.7%). The predominant MDR bacterium was E. coli 60 (47.6%), followed by K. pneumoniae 24 (19.1%), S. aureus 13 (10.3%), P. mirabilis and S. saprophyticus 8 (6.4%), Pseudomonas spp. 6 (4.8%), P. vulgaris 4 (3.2%) and K. rhinos 3 (2.4%). Extensive (XDR) and pan-drug resistant (PDR) isolates were 63 (24.8%) and 6 (4.8%), respectively. Risk factors such as recurrent UTI, hospitalization (≥ 4 days), antibiotic and urinary catheter use were statistically significant. This study found a high prevalence of MDR bacterial isolates in UTI-confirmed geriatrics, with most isolates resistant to tetracycline, beta-lactams, and quinolones. Escherichia coli was the most common MDR and XDR bacteria, while Pseudomonas was the only PDR isolate. Independent risk factors included recurrent UTI, hospitalization (≥ 4 days), antibiotic and urinary catheter use. Therefore, efforts should focus on reducing hospital stays, promoting rational drug use, and further research.

Indexed as

Drug Resistance, Multiple, BacterialUrinary Tract InfectionsAgedAged, 80 and overAnti-Bacterial AgentsCross-Sectional StudiesEthiopiaFemaleGeriatricsHumansMaleMicrobial Sensitivity TestsMiddle AgedPrevalenceProspective StudiesRisk FactorsAnti-Bacterial AgentsBacterial urinary tract infectionGeriatricsMulti-drug resistant

Identifiers

PMID40274838
PMCPMC12022030

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.