Evidence map›Paper›PMID 40274773›Full record

ArticleNature communications2025

A specific microbial consortium enhances Th1 immunity, improves LCMV viral clearance but aggravates LCMV disease pathology in mice.

Daphne Kolland, Miriam Kuhlmann, Gustavo P de Almeida, Amelie Köhler, Anela Arifovic, Alexandra von Strempel, Mohsen Pourjam, Silvia Bolsega, Christine Wurmser, Katja Steiger and 6 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The OMMGut microbes · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daphne KollandCenter of Allergy and Environment (ZAUM), Technical University and Helmholtz Center, Munich, Germany.
Miriam KuhlmannDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Gustavo P de AlmeidaDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0002-2424-9818
Amelie KöhlerCenter of Allergy and Environment (ZAUM), Technical University and Helmholtz Center, Munich, Germany.
Anela ArifovicCenter of Allergy and Environment (ZAUM), Technical University and Helmholtz Center, Munich, Germany.
Alexandra von StrempelMax von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU, Munich, Germany.
Mohsen PourjamCore Facility Microbiome ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0003-3904-8100
Silvia BolsegaInstitute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0009-0003-8290-8214
Christine WurmserDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0003-0649-6206
Katja SteigerInstitute of Pathology, School of Medicine and Health, Technical University Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-7269-5433
Marijana BasicInstitute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-1995-618X
Klaus NeuhausCore Facility Microbiome ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0002-6020-2814
Carsten B Schmidt-WeberCenter of Allergy and Environment (ZAUM), Technical University and Helmholtz Center, Munich, Germany.ORCID http://orcid.org/0000-0002-3203-8084
Bärbel StecherMax von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU, Munich, Germany.ORCID http://orcid.org/0000-0002-7445-5193
Dietmar ZehnDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany. dietmar.zehn@tum.de.ORCID http://orcid.org/0000-0003-1393-8527
Caspar OhnmachtCenter of Allergy and Environment (ZAUM), Technical University and Helmholtz Center, Munich, Germany. caspar.ohnmacht@helmholtz-munich.de.ORCID http://orcid.org/0000-0002-6887-8819

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 395357507 CRC1371 P07, P14, Z01 and Z02EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 716718
6 · The paper itself

Abstract

Anti-viral immunity can vary tremendously from individual to individual but mechanistic understanding is still scarce. Here, we show that a defined, low complex bacterial community (OMM

Indexed as

Gastrointestinal MicrobiomeLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusTh1 CellsAdoptive TransferAnimalsFemaleGerm-Free LifeMiceMice, Inbred C57BLSpecific Pathogen-Free Organisms

Identifiers

PMID40274773
PMCPMC12022176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.