Assessing Tocolytic Potency: Variability and Accuracy of AUC Versus Amplitude-Based Assessment of Pregnant Human Myometrial Contractions Ex Vivo.

Md Reduanul Hossain, Marina Paul, Jorge M Tolosa, Roger Smith, Jonathan W Paul

Abstract readComparative Study

In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Preventing Preterm Birth: The Search for Tocolytic Synergism.Reproductive sciences (Thousand Oaks, Calif.) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Md Reduanul HossainCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia.ORCID 0000-0002-6999-6948

Marina PaulCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia.ORCID 0000-0002-8647-9213

Jorge M TolosaCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia.ORCID 0000-0002-4009-5628

Roger SmithCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia.ORCID 0000-0003-4720-0280

Jonathan W PaulCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia. Jonathan.Paul@newcastle.edu.au.ORCID 0000-0003-3064-6358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The methodological approaches used to evaluate the inhibitory effects (potency determination) of tocolytic agents on human uterine contractions in ex vivo systems vary, and none of the methodologies has been subjected to scrutiny in terms of objectivity, variability, and reliability. Therefore, this study aimed to assess and compare the reliability of using area under the curve (AUC) versus amplitude alone-based assessment of contraction traces to generate concentration-response curves, which were then used to calculate the tocolytic concentrations that inhibited 25% (IC

Indexed as

MyometriumTocolytic AgentsUterine ContractionAdultArea Under CurveDose-Response Relationship, DrugFemaleHumansPregnancyReproducibility of ResultsTocolytic Agents

Identifiers

PMID40274731

DOI10.1007/s43032-025-01864-0

PMCPMC12187858

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.