Evidence map›Paper›PMID 40274672›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Tau profiling across Alzheimer's disease staging reveals vulnerability to disease pathophysiology.

Gleb Bezgin, Tharick A Pascoal, Joseph Therriault, Firoza Z Lussier, Stijn Servaes, Min Su Kang, Mélissa Savard, Cécile Tissot, Jenna Stevenson, Yi-Ting Wang and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Using CA1 rather than the whole hippocampus to capture tau-PET Braak stage II.European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Visual versus quantitative tau-PET Braak staging in Alzheimer's disease using [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Gleb BezginTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada. gleb.bezgin@mcgill.ca.ORCID 0000-0002-1069-9201
Tharick A PascoalTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Joseph TherriaultTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Firoza Z LussierTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Stijn ServaesTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Min Su KangTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Mélissa SavardTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Cécile TissotTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Jenna StevensonTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Yi-Ting WangTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Julie OttoySunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Nesrine RahmouniTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Jaime Fernandez-AriasTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Seyyed Ali HosseiniTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Étienne AumontTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Brandon HallTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Nina Margherita PoltronettiTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Vanessa PallenTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Andréa Lessa BenedetTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Nicholas J AshtonInstitute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Kaj BlennowInstitute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergInstitute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Thomas K KarikariInstitute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Tatsuhiro TeradaDepartment of Biofunctional Imaging, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Mira ChamounTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Sulantha MathotaarachchiTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Arthur Cassa MacedoTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Alyssa StevensonTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Peter KunachTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Gassan MassarwehDepartment of Radiochemistry, McGill University, Montréal, QC, Canada.
Paolo VitaliDepartment of Neurology & Neurosurgery, McGill University, Montréal, QC, Canada.
Jean-Paul SoucyDepartment of Neurology & Neurosurgery, McGill University, Montréal, QC, Canada.
Yasser Iturria-MedinaNeuroinformatics for Personalized Medicine lab, Montreal Neurological Institute, McGill University, Montréal, QC, Canada.
Serge GauthierTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.

Funding

Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in bloodR01AG083874 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas K Karikari · 2023 to 2026
$14.5M
CIHR MOP-11-51-31NIA NIH HHS R01 AG083874
6 · The paper itself

Abstract

backgroundInter-individual variability in tau topography challenges the propagation hypothesis of tau aggregates.

methodsTo address this gap, we propose the Manifold Component Analysis (MCA), for identifying pseudo-continuous profiles informed by the spatial continuity of stage regions.

resultsLongitudinal and cross-sectional MCA in large aging cohort identified individual profiles (N = 753) expressing tau load in the entorhinal, limbic and neocortical regions. Using these profiles, we found neuropsychological and blood-based milestones of early and late disease stages. Finally, we also found evidence of rapid tau load increases and cognitive decline centered at the early-to-mid neocortical stages of Alzheimer's disease.

conclusionsStage system based on tau load and spreading profiles across cortical areas provide a compelling framework for inferring pathophysiological prognosis in Alzheimer's disease.

Indexed as

Alzheimer Diseasetau ProteinsAgedAged, 80 and overFemaleHumansMalePositron-Emission Tomographytau Proteins18F-MK6240 PETAlzheimer’s diseaseComponent analysisDimensionality reductionNeurofibrillary tanglesPET braak stagingPropagationTau

Identifiers

PMID40274672
PMCPMC12397142

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.