ArticleEuropean journal of nutrition2025
Vitamin D deficiency promotes intervertebral disc degeneration via p38/NCoR2-mediated extracellular matrix degradation.
Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- E3 ubiquitin ligases in bone homeostasis: from regulatory mechanisms to skeletal diseases and therapeutic targeting.Frontiers in cell and developmental biology · 2026Review
- Unveiling key genes for intervertebral disc degeneration prediction and potential drug discovery.Scientific reports · 2025Article
- IL-34 as a Novel Mediator Linking Vitamin D Deficiency with Osteoporosis and Knee Osteoarthritis.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeVitamin D (VD) deficiency significantly contributes to intervertebral disc degeneration (IDD), a common cause of low back pain, yet the underlying mechanisms remain unclear. This study investigates how VD deficiency exacerbates IDD and identifies potential therapeutic targets.
methodsWe used real-time quantitative PCR, immunoblots, immunoprecipitation, liquid chromatography with tandem mass spectrometry analysis, co-immunoprecipitation, and chromatin immunoprecipitation to study gene and protein expressions, protein complex assembly, and transcriptional complex binding. Degeneration of IVDs was assessed via hematoxylin and eosin staining.
resultsEight members of ADAMTSs (A disintegrin and metalloproteinase with thrombospondin motifs) are enriched in lumbar discs of both VD-deficient and VD receptor (VDR)-knockout (VDR
conclusionOur findings highlight NCoR2 degradation, mediated by p38 kinase and CRL4 E3 ligase, as crucial in VD deficiency-induced IDD. Targeting this pathway offers promising therapeutic potential to mitigate IDD progression in individuals with VD deficiency or VDR abnormalities.
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Registered trials
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