Evidence map›Paper›PMID 40274366›Full record

ArticleAJNR. American journal of neuroradiology2025

A Comparative Study of CT Perfusion Postprocessing Tools in Medium/Distal Vessel Occlusion Stroke.

Helene Corbaz, Nikolaos Ntoulias, Alex Brehm, Julia Wolleb, Philippe Claude Cattin, Florentin Bieder, Victor Schulze-Zachau, Marios-Nikos Psychogios

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Helene CorbazFrom the Department of Biomedical Engineering (H.C., J.W., P.C.C., F.B.), University Basel, Basel, Switzerland.
Nikolaos NtouliasDepartment of Diagnostic & Interventional Neuroradiology (N.N., A.B., V.S.-Z., M.-N.P.), Radiology & Nuclear Medicine Clinic, University Hospital Basel, Basel, Switzerland.
Alex BrehmDepartment of Diagnostic & Interventional Neuroradiology (N.N., A.B., V.S.-Z., M.-N.P.), Radiology & Nuclear Medicine Clinic, University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-1630-6210
Julia WollebFrom the Department of Biomedical Engineering (H.C., J.W., P.C.C., F.B.), University Basel, Basel, Switzerland.
Philippe Claude CattinFrom the Department of Biomedical Engineering (H.C., J.W., P.C.C., F.B.), University Basel, Basel, Switzerland.ORCID 0000-0001-8785-2713
Florentin BiederFrom the Department of Biomedical Engineering (H.C., J.W., P.C.C., F.B.), University Basel, Basel, Switzerland.
Victor Schulze-ZachauDepartment of Diagnostic & Interventional Neuroradiology (N.N., A.B., V.S.-Z., M.-N.P.), Radiology & Nuclear Medicine Clinic, University Hospital Basel, Basel, Switzerland victor.schulze-zachau@usb.ch.ORCID 0000-0003-0945-8379
Marios-Nikos PsychogiosDepartment of Diagnostic & Interventional Neuroradiology (N.N., A.B., V.S.-Z., M.-N.P.), Radiology & Nuclear Medicine Clinic, University Hospital Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCTP has been validated for stroke due to large vessel occlusion, but not for medium or distal vessel occlusions (MDVO). The aim of this study was to evaluate discrepancy of 2 widely used postprocessing tools for CTP in patients with medium/distal vessel occlusion (MDVO) stroke. MATERIALS AND

methodsThis retrospective single-center cohort study comprised CTP data sets of patients with acute isolated MDVO and disabling stroke. CTP postprocessing included Syngo.via and RapidAI. Perfusion lesions were segmented and compared with regard to volume and spatial distribution of the perfusion abnormalities. For each patient, the results of the 2 postprocessing tools were deemed to represent agreement regarding volume and/or distribution according to a predefined classification scheme. Penumbra volumes were compared between postprocessing tools by using the

resultsFifty CTP data sets from 49 patients (mean age 75.3 ± 10.7 years, 33 male patients) were included. In <30% of patients, the predefined criteria for agreement were met which indicate at least 50% congruence regarding lesion size and lesion location as well as a maximum distance between lesion margins <50 mm. Comparison of tissue at risk volumes revealed outliers, volume disagreement, and distribution disagreement in up to 79.6%. The 2 postprocessing tools disagreed on presence and volume of an infarct core in up to 86% of patients. Penumbra volumes differed significantly between postprocessing tools (

conclusionsDespite being in daily use, commercially available postprocessing tools for CTP provide discrepant results in patients with MDVO.

Indexed as

Radiographic Image Interpretation, Computer-AssistedStrokeTomography, X-Ray ComputedAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedReproducibility of ResultsRetrospective Studies

Identifiers

PMID40274366
PMCPMC12091985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.