SynthesisBMJ open ophthalmology2025
Is there evidence for changes in antibiotic resistance of microorganisms causing postcataract surgery endophthalmitis: a systematic review.
Synthesis in BMJ open ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Antimicrobial resistance in post-cataract endophthalmitis: a systematic review on resistance pattern and treatment outcomes.International ophthalmology · 2026Pooled it
- Intracameral moxifloxacin for endophthalmitis prophylaxis after cataract surgery: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTo review the evidence for changes in antibiotic resistance patterns before and after cataract surgery since the advent of routine use of intracameral (IC) antibiotic prophylaxis and development of newer topical fluoroquinolones pre- and postcataract surgery.
methodsLiterature searches in the National Library of Medicine PubMed database were conducted between 2019 and 2021 and updated in 2024. There were no date restrictions, and the search was limited to high-quality studies published in English. The initial combined searches yielded 583 articles, and the search update in 2024 yielded 9 articles. Of these 592 articles, 26 presented original research that met specified inclusion criteria. Reviewed studies were rated based on the Oxford Centre for Evidence-Based Medicine grading system. Because results from the various studies are not directly comparable due to the use of different antibiotics, different methods, different study populations and different outcomes, formal analyses for heterogeneity of results and publication bias were not performed.
resultsThere were no studies that presented definitive level I evidence for increased bacterial resistance to IC or oral antibiotics prior to or during routine cataract surgery. There were no studies that provided level I evidence for increased bacterial resistance to topical administration of antibiotics. One study showed level III evidence for potential antibiotic resistance when the antibiotic was administered for greater than 1 month, and four level III studies showed a possible trend towards increased moxifloxacin and ciprofloxacin resistance.
conclusionsThere is little evidence of increased bacterial resistance following the use of newer fluoroquinolone antibiotic prophylaxis prior to cataract surgery or the routine use of IC antibiotic prophylaxis during cataract surgery. Our work is limited by the lack of high-level evidence on antibiotic resistance. Many studies reviewed are not randomised controlled trial (RCTs), introducing biases and confounding factors. Small sample sizes further reduce reliability, and uncontrolled variables, such as regional prescribing patterns, may lead to misleading results. While lower level evidence offers some insights, cautious interpretation is advised until more rigorous RCTs are conducted.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.