ArticleACS applied bio materials2025
Shear and Compressive Stiffening of Dual-Cross-Linked Alginate Hydrogels with Tunable Viscoelasticity.
Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Mechanical cues of an interpenetrating polysaccharide matrix regulate self-assembly of collagen fibers.Science advances · 2026Article
- Mechanical licensing of functional dendritic cell states for enhanced T cell priming.bioRxiv : the preprint server for biology · 2026Article
- Cell-Mediated Mechanical Stability Enhancement of Biomimetic Collagen-Alginate Hydrogels: A Mechanistic Study on the Two-Dimensional Extracellular Matrix-Cell Interaction.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- Article
- Matrix Stiffness Governs Fibroblasts' Regulation of Gingival Immune Homeostasis.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- A review on thermoresponsive PNIPAM hydrogels for regenerative medicine: from mechanical design to tissue adhesion.Regenerative biomaterials · 2026Review
- Matrix Stiffness Governs Fibroblast-Driven Immune Homeostasis in Gingival Tissues.bioRxiv : the preprint server for biology · 2025Article
- Modeling tumor transport and growth with poroelastic biopolymer networks.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Alginate biopolymers were modified with norbornene (Nb) and tetrazine (Tz) functional groups to generate hydrogel networks with tunable ionic and covalent cross-linking for modeling the strain-stiffening behavior of extracellular matrix. The mechanical properties of the hydrogels were investigated by oscillatory shear rheology, axial compression, and stress relaxation analysis. Introducing Nb-Tz irreversible covalent cross-links yielded dual-cross-linked hydrogels with stiffer and more elastic properties compared to purely ionically cross-linked alginate networks. The strain stiffening effect was observed under both shear amplitude sweeps and stepwise axial compression tests for the dual-cross-linked hydrogels. This study provides valuable insights into the structure-property relationship of dual-cross-linked biopolymer hydrogels for designing tunable extracellular matrix mimics of fibrotic tissues.
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Registered trials
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