Evidence map›Paper›PMID 40274111›Full record

ArticleJournal of affective disorders2025

Dimensional foundations toward a novel nosology addressing comorbidity: Preadolescent syndrome profiles.

Johanna C Walker, Alyssa J Parker, Krupali R Patel, Lea R Dougherty, Jillian Lee Wiggins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Johanna C WalkerJoint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA. Electronic address: jcwalker@sdsu.edu.
Alyssa J ParkerDepartment of Psychology, University of Maryland, College Park, MD, USA.
Krupali R PatelDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Lea R DoughertyDepartment of Psychology, University of Maryland, College Park, MD, USA.
Jillian Lee WigginsJoint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA; Department of Psychology, San Diego State University, San Diego, CA, USA.

Funding

Neural mechanisms of risk for irritability across the transition to adolescenceR01MH122487 · NIMH · SAN DIEGO STATE UNIVERSITY · PI DOUGHERTY, LEA R, WIGGINS, JILLIAN LEE · 2021 to 2025
$1.8M
Advanced data analytics training for behavioral and social sciences researchT32MH122376 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEKLER, ERIC, POLITIS, DIMITRIS · 2020 to 2024
$1.3M
NIMH NIH HHS R01 MH122487NIMH NIH HHS T32 MH122376
6 · The paper itself

Abstract

objectiveTraditional categorical systems for diagnosing psychopathological symptoms, such as the DSM-5, face limitations including high comorbidity rates and insufficient support for transdiagnostic treatment protocols. Dimensional, person-centered approaches can address these limitations by focusing on cross-cutting psychiatric symptoms.

methodThis study leverages data from the Adolescent Brain Cognitive Development℠ Study (ABCD Study®) to develop dimensional models of preadolescent psychopathology, focusing on a large, diverse sample of youths aged 9-10. We used latent profile analysis (LPA) on Child Behavior Checklist (CBCL) syndrome scales collected from an elevated symptomatology subsample to delineate subgroups for targeted interventions.

resultsFour distinct profiles emerged: "Mildly Elevated" and "Highly Elevated" (on both internalizing and externalizing), "Moderately Elevated - Rule-Breaking," and "Moderately Elevated - Internalizing & Thought Problems." These profiles differed significantly across sociodemographic, neurocognitive, and life experience characteristics. The "Highly Elevated" group showed the highest levels of risk, including greater trauma exposure and higher rates of parental psychopathology. In contrast, the "Mildly Elevated" group demonstrated lower levels of risk factors and higher fluid intelligence compared to the other groups. The two Moderately Elevated profiles were largely similar across most risk indicators, though the Internalizing & Thought Problems group had a slightly higher proportion of parents with a college education.

conclusionsThese profiles offer the beginnings of a foundation for classifying symptom co-occurrence and highlight the need for developmentally specific nosologies to improve risk detection and intervention strategies. Future research should further validate these profiles and explore their stability across developmental stages to inform targeted interventions.

Indexed as

Child Behavior DisordersMental DisordersChildComorbidityDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleRisk FactorsSyndromeExternalizingInternalizingPreadolescencePsychopathologyRisk factors

Identifiers

PMID40274111
PMCPMC12398404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.