Evidence map›Paper›PMID 40273963›Full record

Trial reportJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2025

Determinants of post-stroke cognitive impairment in patients with periodontal disease.

Karly Pikel, Lawson Logue, Haley Verkuilen, Stefanie Wood, Arianne Fritts, Jacobo Mintzer, Leonardo Bonilha, Pramod Sethi, Anne Beckwith, David Huang and 1 more

Registry-linked trialAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02541032 (PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02541032 phase3unknown statusnot on this map

PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke

TypeinterventionalSponsorUniversity of South CarolinaRan2015 to 2020Enrolled400ConditionsPeriodontal Disease, Stroke, TIAArmsIntensive dental treatment, Standard dental treatment, Arestin
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Karly PikelDepartment of Neurology, University of South Carolina School of Medicine and Prisma Health Midlands, 1 Medical Park Suite 230, Columbia, SC 29203, USA.
Lawson LogueDepartment of Neurology, University of South Carolina School of Medicine and Prisma Health Midlands, 1 Medical Park Suite 230, Columbia, SC 29203, USA.
Haley VerkuilenDepartment of Neurology, University of South Carolina School of Medicine and Prisma Health Midlands, 1 Medical Park Suite 230, Columbia, SC 29203, USA.
Stefanie WoodDepartment of Neurology, University of South Carolina School of Medicine and Prisma Health Midlands, 1 Medical Park Suite 230, Columbia, SC 29203, USA.
Arianne FrittsMedical University of South Carolina Department of Health Studies, 316 Calhoun St, 5th Floor, CBRI, Charleston, SC 29401, USA.
Jacobo MintzerMedical University of South Carolina Department of Health Studies, 316 Calhoun St, 5th Floor, CBRI, Charleston, SC 29401, USA.
Leonardo BonilhaDepartment of Neurology, University of South Carolina School of Medicine and Prisma Health Midlands, 1 Medical Park Suite 230, Columbia, SC 29203, USA.
Pramod SethiMoses Cone Health System Department of Neurology, 912 Third St #101, Greensboro, NC, 27405, USA.
Anne BeckwithUniversity of North Carolina Department of Neurology, 101 Manning Dr, Chapel Hill, NC 27514, USA.
David HuangUniversity of North Carolina Department of Neurology, 101 Manning Dr, Chapel Hill, NC 27514, USA.
Souvik SenDepartment of Neurology, University of South Carolina School of Medicine and Prisma Health Midlands, 1 Medical Park Suite 230, Columbia, SC 29203, USA. Electronic address: souvik.sen@uscmed.sc.edu.

Funding

PeRiodontal treatment to Eliminate Minority InEquality and Rural disparities in Stroke (PREMIERS)R01MD009738 · NIMHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SEN, SOUVIK · 2015 to 2019
$3.4M
NIMHD NIH HHS R01 MD009738
6 · The paper itself

Abstract

introductionPeriodontal disease (PD) is a risk factor for stroke and cardiovascular disease. The effect of PD on post-stroke cognitive impairment (PSCI) remains underexplored.

methodsA cross-sectional analysis of the Periodontal tReatment to Eliminate Minority InEquality and Rural disparities in Stroke (PREMIERS) study participants was conducted. Baseline cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) within 90 days of the index event. MoCA score ≤21 indicated severe PSCI. White matter hyperintensity, indicating cerebral small vessel disease (cSVD), was evaluated using the Fazekas scale on MRI. Due to non-normal MoCA distribution, two analytical approaches were employed: 1) logistic regression using dichotomized MoCA scores based on clinically relevant cutoffs and 2) generalized linear mixed modeling after bootstrap normalization that examined MoCA scores continuously.

resultsAmong 280 participants with PD, 48% exhibited severe PSCI. Both analytical approaches demonstrated that severe PD, African American (AA) race, and greater stroke severity significantly and independently predicted severe PSCI, while advanced education was protective. Fazekas' scale showed no significant associations with PSCI.

conclusionsThis study identifies PD severity as a novel and independent contributor to early PSCI. Traditional predictors like AA race, educational attainment, and stroke severity remained significant. CLINICAL TRIAL REGISTRATION INFORMATION: https://www. CLINICALTRIALS: gov; Unique identifier: NCT02541032.

Indexed as

CognitionCognitive DysfunctionPeriodontal DiseasesStrokeAgedBlack or African AmericanCross-Sectional StudiesEducational StatusFemaleHumansMaleMental Status and Dementia TestsMiddle AgedPrognosisRisk AssessmentRisk FactorsCognitionPeriodontal diseaseRaceStroke

Identifiers

PMID40273963
PMCPMC12163726

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.