Evidence map›Paper›PMID 40273528›Full record

ArticleNeurobiology of aging2025

Alzheimer's disease cerebrospinal fluid biomarker levels and APOE genetic status are associated with hippocampal-cerebellar functional connectivity.

Elizabeth R Paitel, Corinne Pettigrew, Abhay Moghekar, Michael I Miller, Andreia V Faria, Marilyn Albert, Anja Soldan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. ApoE4 Homozygosity Is Associated With Increased Microglia Activation in Fatal COVID-19.Neuropathology : official journal of the Japanese Society of Neuropathology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth R PaitelDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: epaitel1@jhmi.edu.
Corinne PettigrewDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abhay MoghekarDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael I MillerDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Andreia V FariaDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Marilyn AlbertDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anja SoldanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Regulatory and Human Study Operations (RHSO) Core CU19AG065169 · NIA · UNIVERSITY OF ARIZONA · PI HUENTELMAN, MATT · 2021 to 2025
$59.8M
Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT, Arnold Bakker · 2014 to 2026
$51.5M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Research Training in Age-Related Cognitive DisordersT32AG027668 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2007 to 2026
$6.3M
NIA NIH HHS P30 AG066507NIA NIH HHS T32 AG027668NIA NIH HHS U19 AG033655NIA NIH HHS U19 AG065169NIBIB NIH HHS P41 EB031771
6 · The paper itself

Abstract

Recent research suggests that hippocampal-cerebellar (Hp-CB) functional connectivity may be altered early in the course of Alzheimer's disease (AD), given the early accumulation of AD pathology in the hippocampi and emerging evidence of cerebellar changes in early AD. This study analyzed the role of AD genetic risk (via APOE ε4 carrier status) and cerebrospinal fluid (CSF) biomarkers of AD pathology (ratio of phosphorylated tau (p-tau

Indexed as

Alzheimer DiseaseApolipoprotein E4Apolipoproteins ECerebellumHippocampusAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPeptide Fragmentstau ProteinsAmyloid beta-PeptidesApolipoprotein E4Apolipoproteins EBiomarkersPeptide Fragmentstau ProteinsAlzheimer's diseaseApoECerebellumCerebrospinal fluidHippocampusMemoryResting-state fMRI

Identifiers

PMID40273528
PMCPMC12101073

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.