Observational studyClinics (Sao Paulo, Brazil)2025
Clinical characteristics, SARS-CoV-2 variants, and outcomes of adults hospitalized due to COVID-19 in Latin American countries.
Observational study in Clinics (Sao Paulo, Brazil), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05282017 (LatInamerican Vaccine Effectiveness Against Hospitalizations Due to Circulating COVID-19 VoC RWE Study), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
LatInamerican Vaccine Effectiveness Against Hospitalizations Due to Circulating COVID-19 VoC RWE Study
Who cites it
1 citing paper in PubMed.
- MIS-C pathogenesis: immune dysregulation & viral triggers.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCOVID-19 vaccines prevented severe disease outcomes worldwide. As part of a vaccine effectiveness study, the authors summarized demographic and health profiles, vaccination data, SARS-CoV-2 variants, and disease outcomes from patients hospitalized due to COVID-19-like symptoms in Latin America between February and December 2022.
methodsLIVE was an observational-prospective study with a test-negative case-control design (NCT05282017). Adults admitted with COVID-19-like symptoms were recruited across five Latin American countries. Patients were tested for SARS-CoV-2, and variants were identified through sequencing. Data were collected from medical records and interviews.
resultsParticipants recruited (536 cases, 250 controls) had a mean age of 60.5 years. COVID-19 cases (63.7, SD = 19.1) were slightly older than controls (53.8, SD = 20.4). Disorders of the cardiovascular system were the most prevalent comorbidities, and most participants (73.0 %) reported at least one comorbidity. COVID-19 cases mostly presented with moderate (51.1 %) disease. Overall, 50.6 % of participants were unvaccinated against COVID-19, with a higher percentage in cases (56.3 %) than in controls (38.2 %). Viral genomic analysis identified the most prevalent SARS-CoV-2 lineages, BQ.1.1 (11.9 %) among Omicron BA.5 and XBB.1.15 (2.5 %) among recombinant variants. The study was underpowered to estimate vaccine effectiveness due to the low number of COVID-19 hospitalization cases.
conclusionThe present study revealed key demographic and clinical characteristics of patients hospitalized due to COVID-19. Notably, an older age among confirmed cases, a substantial proportion of unvaccinated individuals, and the decrease in hospitalizations emphasize the complexity of the COVID-19 landscape in Latin America and the need for continued research to inform public health strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.