Evidence map›Paper›PMID 40273424›Full record

ArticleEnvironmental health perspectives2025

Effects of Long-Term Air Pollution Exposure on Disease Outcomes and Hybrid Immune Responses in SARS-CoV-2 Breakthrough Infections: A Study of the Yichang COVID-19 Antibody Longitudinal Survey (YC-CALS) in China.

Xiaolong Yan, Yin Du, Ke Li, Xin Zhao, Hao Wang, Li Liu, Qi Wang, Jianhua Liu, Sheng Wei

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PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiaolong YanSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China.
Yin DuCenter for Disease Control and Prevention, Yichang, Hubei, China.
Ke LiSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xin ZhaoCenter for Disease Control and Prevention, Yichang, Hubei, China.
Hao WangSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li LiuSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qi WangSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jianhua LiuCenter for Disease Control and Prevention, Yichang, Hubei, China.
Sheng WeiSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs immunity wanes and viral mutations continue, the risk of endemic SARS-CoV-2 breakthrough infections (BTIs) remains. Air pollution is considered a risk factor for respiratory infection, but evidence of its association with SARS-CoV-2 BTIs is limited.

objectivesWe aimed to examine the effects of long-term exposure to air pollution on disease outcomes, immune responses, and antibody dynamics of SARS-CoV-2 BTIs.

methodsWe gathered data on self-reported SARS-CoV-2 infections through questionnaires and measured IgG antibody levels using serological assays from a total of 6,875 participants from the Yichang COVID-19 Antibody Longitudinal Survey cohort in China. Air pollutant exposure [particulate matter (PM) with an aerodynamic diameter

resultsPer interquartile range (IQR) increase in DISCUSSION: Long-term exposure to air pollution increases the risk of SARS-CoV-2 BTIs and disease severity while weakening the immune response, particularly for vulnerable populations. https://doi.org/10.1289/EHP15660.

Indexed as

Air PollutantsAir PollutionCOVID-19Environmental ExposureAdultAgedAntibodies, ViralBreakthrough InfectionsChinaFemaleHumansImmunoglobulin GLongitudinal StudiesMaleMiddle AgedParticulate MatterAir PollutantsAntibodies, ViralImmunoglobulin GParticulate Matter

Identifiers

PMID40273424
PMCPMC12110910

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.