ArticleChemistry & biodiversity2025
Antileishmanial Activities of Carvacrol Nanoencapsulate in Biopolymeric Nanoparticles.
Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Antileishmanial Activities of Carvacrol Nanoencapsulate in Biopolymeric Nanoparticles.Chemistry & biodiversity · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Visceral leishmaniasis (VL) is a neglected parasitic disease, and the first-line treatments for VL include drugs that exhibit serious toxicological issues. In this sense, new molecules are sought for VL treatment, such as Carvacrol (Car), a phenolic monoterpene that has shown strong activity against Leishmania spp. However, its low solubility prevents its free administration, requiring a new therapeutic strategy such as encapsulation in chitosan biopolymeric nanoparticles. This study aimed to develop chitosan biopolymeric nanoparticles (NPChi) encapsulating Car (NPCar) and evaluate their in vitro anti-leishmanial activity. The NPChi had particle sizes of 89.43 ± 0.774 nm, a polydispersity index (PDI) of 0.168 ± 0.01 and zeta potential of 12.8 ± 2.17 mV. The NPCar showed particle size of 144.9 ± 1.7 nm, PDI of 0.224 and zeta potential of 15.7 ± 1.01 mV. NPCar reduced the cytotoxicity of Car on human erythrocytes. Moreover, NPCar showed inhibition of Leishmania infantum with an inhibitory concentration (IC
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Registered trials
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