ArticleG3 (Bethesda, Md.)2025
Three annotated chromosome-level de novo genome assemblies of Lomentospora prolificans provide evidence for a chromosomal translocation event.
Nina T Grossman, Yunfan Fan, Aleksey V Zimin, Maggie P Wear, Anne Jedlicka, Amanda Dziedzic, Livia C Liporagi-Lopes, Winston Timp, Arturo Casadevall
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In one paragraphArticle in G3 (Bethesda, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Nina T GrossmanDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, United States.ORCID 0000-0003-1976-9357 Yunfan FanDepartment of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, United States.
Aleksey V ZiminDepartment of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, United States.
Maggie P WearDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, United States.
Anne JedlickaDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, United States.
Amanda DziedzicDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, United States.
Livia C Liporagi-LopesDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, United States.
Winston TimpDepartment of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, United States.ORCID 0000-0003-2083-6027 Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, United States.ORCID 0000-0002-9402-9167 Funding
Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9MSynergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4MBiology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6MThe biology of Cryptococcus neoformans melanizationR01AI171093 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall, JOSHUA D NOSANCHUK · 2023 to 2026
$3.2MCanadian Institutes of Health Research Doctoral Foreign Study AwardNHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI171093NIAID NIH HHS T32 AI007417NIH HHS 5-T32-AI-7417-22NIH HHS AI052733NIH HHS AI15207NIH HHS AI171093-01NIH HHS HL059842
6 · The paper itselfAbstract
Lomentospora prolificans is a fungal pathogen responsible for serious, often fatal, illness in patients with compromised immune systems. Treatment is rarely successful because L. prolificans is inherently resistant to all major classes of antifungal drugs. In this study, we publish 3 chromosome-level de novo genome assemblies, including the first complete-level assembly of L. prolificans, along with genome annotations. The L. prolificans genome is packaged in 11 nuclear chromosomes and 1 mitochondrial chromosome, has 36.7-37.1 Mb, and encodes for a putative 7,357-7,640 genes. The length and composition of contigs in 1 strain varied from those of the other 2 strains, supporting the hypothesis that a chromosomal translocation took place. These assemblies were confirmed with pulsed-field gel electrophoresis. The availability of more complete genomes will hopefully help the search for new antifungal drugs and provides insights into the evolutionary history of this pathogenic fungus.
Indexed as
Chromosomes, FungalGenome, FungalMolecular Sequence AnnotationTranslocation, GeneticGenomicschromosomal translocationgenome assemblyLomentospora prolificanssubtelomere
Identifiers
PMID40273388
PMCPMC12134988
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LicenceCC BY
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