Evidence map›Paper›PMID 40273333›Full record

ArticleBiochemistry2025

Kinetic Mechanism of the Emergent Anticancer Target, Human ADP-ribosyltransferase 1.

Daniel P Groom, Amanda Lopacinski, Scott J Garforth, Vern L Schramm

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Transition-state analysis of the arginine-specific human ADP-ribosyltransferase 1.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel P GroomDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0009-0004-9353-1851
Amanda LopacinskiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Scott J GarforthDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Vern L SchrammDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0000-0002-8056-1929

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONSR01GM041916 · NIGMS · YESHIVA UNIVERSITY · PI SCHRAMM, VERN L. · 1989 to 2023
$10.0M
TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONSR37GM041916 · NIGMS · YESHIVA UNIVERSITY · PI SCHRAMM, VERN L. · 1998 to 2007
$3.5M
NCI NIH HHS P30 CA013330NIGMS NIH HHS R01 GM041916NIGMS NIH HHS R37 GM041916NIH HHS GM041916
6 · The paper itself

Abstract

Human ADP-ribosyltransferase 1 (

Indexed as

ADP Ribose TransferasesAdenosine Diphosphate RiboseADP-RibosylationArginineHumansKineticsNADSubstrate SpecificityAdenosine Diphosphate RiboseADP Ribose TransferasesArginineNAD

Identifiers

PMID40273333
PMCPMC12990283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.