Observational studyRevista medica del Instituto Mexicano del Seguro Social2025
[ART adherence and its association with depression, anxiety and stress].
Observational study in Revista medica del Instituto Mexicano del Seguro Social, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
Background: Stress, anxiety, and depression are associated with low adherence to antiretroviral therapy (ART) in HIV patients, but there are no reports of this association in southeastern Mexico. Objective: To describe the frequency of adherence to ART and its association with depression, anxiety, and stress. Material and methods: A cross-sectional study was conducted. 442 HIV-positive outpatients treated at General Hospital Number 1 in Tapachula, Chiapas, in the period August-December 2022 were analyzed. Adherence to ART was assessed with the Simplified Medication Adherence Questionnaire (SMAQ) and the Depression, Anxiety, and Stress Scale-21 (DASS-21) was applied. To assess the association between variables, adjusted odds ratios (aOR) with 95% confidence intervals (CI) were calculated using a multivariate logistic regression model. Cases with ART adherence between 95% and 100% were compared with those with ART adherence below 95%. Results: Of the total 442 HIV-positive subjects, 344 had ART adherence between 95% and 100%, and 98 had ART adherence below 95%. The frequencies of depression, anxiety, and stress were 33%, 13.3%, and 8.8%, respectively. Associations were observed between ART adherence below 95% and anxiety, depression, and stress. Conclusions: Since low ART adherence was associated with depression, anxiety, and stress among HIV-positive patients, early mental health interventions may help improve therapeutic adherence.
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