ArticleJournal of agricultural and food chemistry2025
Metabolic Profiling of a Mediterranean-Inspired (Poly)phenol-Rich Mixture in the Brain: Perfusion Effect and
Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Epigenetic regulators polyphenols in neurodegenerative diseases: a promising intervention strategy.Annals of medicine · 2026Review
- Effects of Plant Polyphenols on Obesity-Induced Inflammatory Depression: A Review.International journal of molecular sciences · 2026Review
- Phenolic Compounds of Olive Oil: Intake and Behavior in In Vitro Static Simulated Digestion Without or with Cellulose.Molecules (Basel, Switzerland) · 2026Article
- Neuroprotective Effect of Physiological Circulating Phenolic Metabolites Against Oxidative Stress- and Neuroinflammation-Induced in Human Cellular Models.International journal of molecular sciences · 2026Article
- Metabolic fate of rambutan (Food chemistry: X · 2026Article
- Buckwheat Flavonoids Modulate Inflammation in RAW 264.7 Macrophages at Physiologically Relevant Concentrations via the LPS/COX-2 Pathway.Journal of agricultural and food chemistry · 2026Article
- Polyphenols Bioactive Metabolites, and Their Anti-Biofilm and Neuroprotective Potential.Foods (Basel, Switzerland) · 2025Review
- Novel Ingredients: Hydroxytyrosol as a Neuroprotective Agent; What Is New on the Horizon?Foods (Basel, Switzerland) · 2025Review
- Polyphenols and Fibre: Key Players with Antioxidant Activity in Two Extracts from Pomegranate (International journal of molecular sciences · 2025Article
- Hydroxytyrosol and Brain Tumors: Mechanisms of Action and Therapeutic Potential.Current issues in molecular biology · 2025Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A Mediterranean diet rich in (poly)phenols has been linked to neuroprotection, but its effects likely depend on the ability of phenolic metabolites to cross the blood-brain barrier (BBB). This study evaluated the kinetics plasma and brain distribution of phenolic metabolites in Sprague-Dawley rats following oral administration of a polyphenol-rich extract mixture from Mediterranean foods (pomegranate, lemon, orange, grape, and olive). UPLC-ESI-QTOF analyses revealed 39 phenolic-derived metabolites in plasma, of which 20 were in nonperfused (NPB) and 19 in perfused brains (PB), including hydroxytyrosol and tyrosol sulfates, ellagic acid, dihydrocaffeic acid, and derived metabolites. Kinetic data showed substantially higher plasma metabolite concentrations than the brain, with slightly higher levels in NPB. The BBB transport efficiency of phenolic metabolites was validated
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.