ArticlePloS one2025
Development of a clinical predictive score for allergic reactions during oral food challenges in pediatric patients.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Improving machine-learning development in allergology: bridging the gap between open-access and cohort-based databases.Current opinion in allergy and clinical immunology · 2026Review
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe oral food challenge (OFC) is the gold standard for diagnosing food allergies; but, it carries risks ranging from mild to life-threatening reactions, including anaphylaxis. Understanding and predicting these reactions is critical for safe clinical practice.
objectivesThis study aimed to develop and validate a clinically predictive score for allergic reactions during OFCs in pediatric patients.
methodsUsing a retrospective database of pediatric patients undergoing OFCs at a pediatric outpatient clinic in Southern Thailand from January 2014 to December 2022, a multivariable predictive model was developed. Data on the reaction rates, demographics, and treatments were collected. Logistic regression analysis with predictor selection using a backward stepwise approach, was employed. The model's performance was assessed using the area under the receiver operating characteristic curve (ROC), calibration, and classification measures.
resultsThis study included 179 patients with an allergic reaction incidence of 12.3%. Predictors encompassed female, anaphylaxis and positive skin prick testing. The developed model achieved an ROC of 0.71. The patients were categorized into the low-risk (score 0-1) and high-risk (score 2-3) groups. Reaction rates during the OFCs were 6.7% in the low-risk group and 29.5% in the high-risk group.
conclusionsOur scoring model demonstrated predictive ability for OFC reactions in pediatric patients, offering valuable insights for clinical risk assessment.
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