Evidence map›Paper›PMID 40273107›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Molecular organization of central cholinergic synapses.

Justin S Rosenthal, Dean Zhang, Jun Yin, Caixia Long, George Yang, Yan Li, Zhiyuan Lu, Wei-Ping Li, Zhiheng Yu, Jiefu Li and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Justin S RosenthalNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-6126-4478
Dean ZhangNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Jun YinNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-4314-4402
Caixia LongNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
George YangNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.ORCID 0009-0004-1778-2755
Yan LiNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-3820-5960
Zhiyuan LuJanelia Research Campus, HHMI, Ashburn, VA 20147.
Wei-Ping LiJanelia Research Campus, HHMI, Ashburn, VA 20147.ORCID 0009-0003-0095-3872
Zhiheng YuJanelia Research Campus, HHMI, Ashburn, VA 20147.
Jiefu LiJanelia Research Campus, HHMI, Ashburn, VA 20147.
Quan YuanNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-0676-2079

Funding

Study dendrite morphogenesis and activity-dependent plasticity using DrosophilaZIANS003137 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI YUAN, QUAN · 2013 to 2025
$24.9M
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1ZIANS003137Howard Hughes Medical Institute (HHMI) group leaderIntramural NIH HHS ZIA NS003137
6 · The paper itself

Abstract

Synapses have undergone significant diversification and adaptation, contributing to the complexity of the central nervous system. Understanding their molecular architecture is essential for deciphering the brain's functional evolution. While nicotinic acetylcholine receptors (nAchRs) are widely distributed across metazoan brains, their associated protein networks remain poorly characterized. Using in vivo proximity labeling, we generated proteomic maps of subunit-specific nAchR interactomes in developing and mature

Indexed as

Cholinergic NeuronsDrosophila ProteinsReceptors, NicotinicSynapsesAnimalsBrainDrosophila melanogasterNeuronal PlasticityProteomeProteomicsDrosophila ProteinsProteomeReceptors, Nicotiniccholinergic synapseDrosophilanicotinic acetylcholine receptorpostsynaptic densityproteomics

Identifiers

PMID40273107
PMCPMC12054790

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.