Evidence map›Paper›PMID 40273105›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Subunit specialization in AAA+ proteins and substrate unfolding during transcription complex remodeling.

Forson Gao, Fuzhou Ye, Martin Buck, Xiaodong Zhang

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Forson GaoSection of structural and synthetic biology, Department of Infectious Disease, Imperial College London, London SW7 2AZ, United Kingdom.
Fuzhou YeSection of structural and synthetic biology, Department of Infectious Disease, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0003-4724-1533
Martin BuckDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0002-7580-8982
Xiaodong ZhangSection of structural and synthetic biology, Department of Infectious Disease, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-9786-7038

Funding

UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M011178/1Wellcome Trust
6 · The paper itself

Abstract

Bacterial RNA polymerase (RNAP) is a multisubunit enzyme that copies DNA into RNA in a process known as transcription. Bacteria use σ factors to recruit RNAP to promoter regions of genes that need to be transcribed, with 60% bacteria containing at least one specialized σ factor, σ

Indexed as

ATPases Associated with Diverse Cellular ActivitiesBacterial ProteinsTranscription, GeneticAdenosine TriphosphateDNA-Binding ProteinsDNA-Directed RNA PolymerasesModels, MolecularPromoter Regions, GeneticProtein SubunitsRNA Polymerase Sigma 54Adenosine TriphosphateATPases Associated with Diverse Cellular ActivitiesBacterial ProteinsDNA-Binding ProteinsDNA-Directed RNA PolymerasesProtein SubunitsRNA Polymerase Sigma 54AAA+ ATPasesDNA openingprotein unfolding and remodelingRNA polymerasetranscription initiation

Identifiers

PMID40273105
PMCPMC12054792

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.