ArticleJournal of the National Cancer Institute2025
Father's occupation and colorectal cancer in his adult offspring.
Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Occupation Associated with Altered Steroid Hormone Metabolism in Men: A Cross-Sectional Metabolome-Wide Association Study.Research square · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundGrowing evidence suggests transmission of colorectal cancer risk through the maternal line. There is scant information about transmission through the paternal line, despite plausible evidence from mammal experiments.
methodsWe examined the association between paternal occupation and colorectal cancer in the Child Health and Development Studies, a multigenerational cohort followed for 60 years. Pregnant mothers completed in-person interviews at enrollment (1959-1966) and reported demographic and health-related information for her and her husband, including occupation. Colorectal cancer in adult (age ≥18 years) offspring was ascertained from a population-based cancer registry. Cox proportional hazards models were used to estimate adjusted hazard ratios (aHRs), with follow-up accrued from birth through cancer diagnosis, death, or last contact.
resultsPaternal occupations included 37.0% professional, technical, or managerial; 13.7% clerical or sales; 30.5% crafts or operative; and 17.5% service work or labor. Over 716 133.5 person-years of follow-up, 79 offspring were diagnosed with colorectal cancer (median age at diagnosis: 50 years [range = 23-59 years]). Offspring of fathers employed in crafts, operative, service, or labor occupations had higher incidence rates of colorectal cancer (15.66 per 100 000 person-years; 95% confidence interval [CI] = 11.47 to 20.89) compared with professional, technical, or managerial occupations (6.84 per 100 000 person-years; 95% CI = 3.73 to 11.47). Risk associated with these occupations remained elevated after adjustment for maternal race, paternal education, and offspring year of birth (aHR = 1.99; 95% CI = 1.03 to 3.87).
conclusionOur findings support the possible transmission of cancer risk through the paternal line.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.