Evidence map›Paper›PMID 40272861›Full record

ArticleSexually transmitted diseases2025

Syphilis in Pregnant Women and Congenital Syphilis in Japan, 2022 to 2023: A Warning for Other Countries.

Ayu Kasamatsu, Takuri Takahashi, Yuzo Arima, Hanae Ito, Maki Masutani, Shimpei Murai, Natsuko Nakamura, Ayano Orime, Masami Kitaoka, Yukihiro Akeda and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Increase in congenital syphilis in the European Union and European Economic Area, 2015 to 2024 - time to scale-up public health responses.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ayu KasamatsuFrom the Center for Surveillance, Immunization, and Epidemiologic Research.ORCID 0000-0003-1515-6238
Takuri TakahashiFrom the Center for Surveillance, Immunization, and Epidemiologic Research.ORCID 0000-0002-2482-7286
Yuzo ArimaFrom the Center for Surveillance, Immunization, and Epidemiologic Research.ORCID 0000-0002-8711-7636
Hanae ItoField Epidemiology Training Program.
Maki MasutaniField Epidemiology Training Program.
Shimpei MuraiField Epidemiology Training Program.
Natsuko NakamuraField Epidemiology Training Program.
Ayano OrimeField Epidemiology Training Program.
Masami KitaokaField Epidemiology Training Program.
Yukihiro AkedaDepartment of Bacteriology I.ORCID 0000-0002-5325-4173
Motoi SuzukiFrom the Center for Surveillance, Immunization, and Epidemiologic Research.ORCID 0000-0002-8340-0880
Takuya YamagishiCenter for Field Epidemic Intelligence, Research and Professional Development, National Institute of Infectious Diseases, Tokyo, Japan.ORCID 0000-0002-9566-201

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractAfter a brief decline, syphilis case counts among pregnant women reported through Japan's national surveillance doubled from 2021 to 2023; congenital syphilis case counts/100,000 live births also doubled to >5. The unprecedented trends in Japan highlight the current heterosexual syphilis epidemic's relentlessness, with important implications for other countries.

Indexed as

Pregnancy Complications, InfectiousSyphilisSyphilis, CongenitalAdultFemaleHumansInfant, NewbornJapanPregnancy

Identifiers

PMID40272861
PMCPMC12893140

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.