Evidence map›Paper›PMID 40272768›Full record

ArticleMolecular neurobiology2025

Knockdown of ATF3 Alleviates Ischemic Stroke and Inhibits Ferroptosis via Activating the Keap1/Nrf2/HO- 1 Pathway.

Xianghong Liu, Haifengqing Li, Fan Zhang, Cong Zhang, Min Zhou, Qing Liu, Guoyong Zeng

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xianghong LiuDepartment of Neurology, The Affiliated Ganzhou Hospital of Nanchang University, No. 16, Meiguan RD, Zhanggong District, Ganzhou City, 341000, Jiangxi Province, China.
Haifengqing LiDepartment of Neurology, The Affiliated Ganzhou Hospital of Nanchang University, No. 16, Meiguan RD, Zhanggong District, Ganzhou City, 341000, Jiangxi Province, China.
Fan ZhangDepartment of Neurology, The Affiliated Ganzhou Hospital of Nanchang University, No. 16, Meiguan RD, Zhanggong District, Ganzhou City, 341000, Jiangxi Province, China.
Cong ZhangDepartment of Neurology, The Affiliated Ganzhou Hospital of Nanchang University, No. 16, Meiguan RD, Zhanggong District, Ganzhou City, 341000, Jiangxi Province, China.
Min ZhouDepartment of Neurology, The Affiliated Ganzhou Hospital of Nanchang University, No. 16, Meiguan RD, Zhanggong District, Ganzhou City, 341000, Jiangxi Province, China.
Qing LiuDepartment of Neurology, The Affiliated Ganzhou Hospital of Nanchang University, No. 16, Meiguan RD, Zhanggong District, Ganzhou City, 341000, Jiangxi Province, China.
Guoyong ZengDepartment of Neurology, The Affiliated Ganzhou Hospital of Nanchang University, No. 16, Meiguan RD, Zhanggong District, Ganzhou City, 341000, Jiangxi Province, China. hsyygy@126.com.

Funding

National Natural Science Foundation of China 8236050537Natural Science Foundation of Jiangxi Province S2023ZRMSL0428
6 · The paper itself

Abstract

Ischemic stroke is a common event of cerebrovascular disease, and inhibiting ferroptosis is associated with improvement in ischemic stroke. The purpose was to evaluate the effects of activating transcription factor 3 (ATF3) knockdown on ferroptosis in ischemic stroke and to reveal its underlying mechanism. Ischemic condition was simulated in HT22 cells by oxygen glucose deprivation/reperfusion (OGD/R), and an ischemic stroke model was induced by middle cerebral artery occlusion (MCAo) in rats. ATF3 was knocked down to investigate its effects on cerebral infarct size, cell death, oxidative stress, Fe

Indexed as

Activating Transcription Factor 3Brain IschemiaFerroptosisGene Knockdown TechniquesHeme Oxygenase-1Ischemic StrokeKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Signal TransductionAnimalsCell LineInfarction, Middle Cerebral ArteryMaleMiceOxidative StressRatsActivating Transcription Factor 3Heme Oxygenase-1KEAP1 protein, ratKelch-Like ECH-Associated Protein 1Nfe2l2 protein, ratNF-E2-Related Factor 2Reactive Oxygen SpeciesATF3FerroptosisIschemic strokeKeap1/Nrf2/HO- 1Middle cerebral artery occlusionOxygen glucose deprivation/reperfusion

Identifiers

PMID40272768

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.