Evidence map›Paper›PMID 40272737›Full record

ArticleAIDS and behavior2025

Assessing the Implementation Fidelity of a Patient-Centered, Combination Adherence Strategy to Support HIV Antiretroviral Therapy and Pre-Exposure Prophylaxis Adherence During Pregnancy and Breastfeeding in Malawi.

Friday Saidi, Lauren A Graybill, Twambilile Phanga, Katie R Mollan, Getrude Msowoya, Mercy Tsidya, Mary Chindevu, Donnie Makonokaya, Kellie Freeborn, Nora E Rosenberg and 5 more

Abstract read
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In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Friday SaidiUNC Project Malawi, Lilongwe, Malawi. fsaidi@unclilongwe.org.ORCID http://orcid.org/0000-0003-1190-1499
Lauren A GraybillInstitute for Global Health and Infectious Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Twambilile PhangaUNC Project Malawi, Lilongwe, Malawi.
Katie R MollanDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC, USA.
Getrude MsowoyaUNC Project Malawi, Lilongwe, Malawi.
Mercy TsidyaUNC Project Malawi, Lilongwe, Malawi.
Mary ChindevuUNC Project Malawi, Lilongwe, Malawi.
Donnie MakonokayaUNC Project Malawi, Lilongwe, Malawi.
Kellie FreebornDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nora E RosenbergDepartment of Health Behavior, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lauren M HillDepartment of Health Behavior, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sam PhiriPartners in Hope, Lilongwe, Malawi.
Wilbroad MutaleDepartment of Population Studies and Global Health, University of Zambia, Lusaka, Zambia.
Benjamin H ChiDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
K Rivet AmicoDepartment of Health Behavior and Health Equity, University of Michigan, Ann Arbor, MI, USA.

Funding

UJMT – ORWH – Gazzetta, Issa-BoubeD43TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William Checkley, Benjamin H. Chi · 2017 to 2026
$14.8M
Malawi HIV Implementation Research Scientist Training Program (MHIRST)D43TW010060 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MINA CHRISTINE HOSSEINIPOUR, Victor Mwapasa · 2015 to 2026
$3.8M
A dyad approach to combination HIV prevention in pregnancy for Zambia and MalawiR01AI131060 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H., MUTALE, WILBROAD · 2017 to 2020
$2.7M
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1P01HD112215FIC NIH HHS D43 TW009340FIC NIH HHS D43 TW010060NIAID NIH HHS R01 AI131060
6 · The paper itself

Abstract

The use of antiretroviral drugs has been proven effective in preventing and treating HIV; however, adherence remains a challenge. In two parallel pilot studies, we implemented a combination adherence intervention involving patient-centered counseling and adherence supporter training, tailored for HIV treatment (ART) or prevention (PrEP) during pregnancy and breastfeeding. The intervention included Integrated Next Step Counseling (iNSC), focused on well-being and medication adherence, with an option to involve a social support member. Independent auditors assessed implementation fidelity for 151 participants (51 women living with HIV and 100 PrEP-eligible women) by scoring iNSC sessions using a standard checklist. High fidelity was observed overall in both study populations, with variability between counselors observed. The results demonstrate the ability to assess implementation fidelity in a behavioral intervention aimed at supporting adherence to antiretroviral drugs among pregnant women and offers critical information on the complexities of implementation of iNSC in a real-world setting.

Indexed as

Anti-HIV AgentsBreast FeedingHIV InfectionsInfectious Disease Transmission, VerticalMedication AdherencePre-Exposure ProphylaxisPregnancy Complications, InfectiousAdultCounselingFemaleHumansMalawiPatient-Centered CarePilot ProjectsPregnancyPregnant PeopleAnti-HIV AgentsAntiretroviral therapyHIVImplementation fidelityPre-exposure prophylaxisPregnancy

Identifiers

PMID40272737

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.