ArticleBiomechanics and modeling in mechanobiology2025
Tuning the trabecular orientation of Voronoi-based scaffold to optimize the micro-environment for bone healing.
Article in Biomechanics and modeling in mechanobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- [A simulation study on the differences in compressive mechanical properties of Voronoi porous structures with two strut-diameter morphologies].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Design of 3D-printed hydroxyapatite intervertebral fusion cages in a patient specific framework.Medical & biological engineering & computing · 2026Article
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Authors and funding
4 authors.
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Abstract
Voronoi tessellation is a powerful technique for designing random structures for bone tissue engineering applications. In this study, an innovative algorithm for scaffold design that controls trabecular orientation while maintaining an overall random architecture is presented. Morphological analyses and numerical models were employed to comprehensively characterize the scaffolds. The results indicate that the effective stiffness and permeability of the scaffolds are directly influenced by the trabecular orientation. In contrast, other parameters, such as porosity, trabecular thickness, trabecular spacing, and curvatures, can be kept constant with respect to the trabecular orientation. These findings, in conjunction with mechano-biological considerations, provide a robust design workflow to optimize the micro-environment for bone growth. This framework offers a valuable tool for selecting the most suitable scaffold architecture according to the specific external loads, thereby enhancing the efficacy and reliability of bone scaffolds in clinical applications. Through this approach, the aim is to improve the precision and outcomes of bone tissue engineering, contributing to the development of advanced therapeutic solutions for bone repair and regeneration.
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