Evidence map›Paper›PMID 40272693›Full record

ArticleJournal of fluorescence2025

In Silico Structural Study, Design and Efficacy Evaluation of Fluoro Isoxazolidine Derivatives as Potential Antibacterial Agents.

Rachid Boutiddar, Khalid Abbiche, Soukayna Baammi, Abdellatif El Hammadi, Muneerah Mogren Al Mogren, Majdi Hochlaf

Abstract read
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In one paragraph

Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachid BoutiddarNatural Substances and Environment Laboratory, Polydisciplinary Faculty of Taroudant, Analysis, Modeling, Engineering, Ibn Zohr University. Hay El Mohammadi, B. P. 271, Taroudant, 83000, Morocco. rachid.boutiddar@edu.uiz.ac.ma.
Khalid AbbicheNatural Substances and Environment Laboratory, Polydisciplinary Faculty of Taroudant, Analysis, Modeling, Engineering, Ibn Zohr University. Hay El Mohammadi, B. P. 271, Taroudant, 83000, Morocco. k.abbiche@uiz.ac.ma.ORCID https://orcid.org/0000-0002-9081-9380
Soukayna BaammiBioinformatics Laboratory, College of Computing, Mohammed VI Polytechnic University, Ben Guerir, 20670, Morocco.
Abdellatif El HammadiNatural Substances and Environment Laboratory, Polydisciplinary Faculty of Taroudant, Analysis, Modeling, Engineering, Ibn Zohr University. Hay El Mohammadi, B. P. 271, Taroudant, 83000, Morocco.
Muneerah Mogren Al MogrenDepartment of Chemistry, College of Sciences, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Majdi HochlafUniversité Gustave Eiffel. COSYS/IMSE, 5 Bd Descartes, Champs sur Marne, 77454, France. majdi.hochlaf@univ-eiffel.fr.ORCID https://orcid.org/0000-0002-4737-7978

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The decreasing efficacy of traditional antibiotics due to increasing antimicrobial resistance represents an urgent challenge. This study presents a comprehensive in silico study of the antibacterial potential of novel fluoroisoxazolidine derivatives, complementing Chakraborty in vitro results to assess their antimicrobial efficacy. Using computational modeling, including density functional theory (DFT), ADMET analysis, and molecular docking simulations, we explore their electronic properties, biological interactions, and pharmacokinetic profiles. In particular, we provide their optimized molecular structures and NMR spectra (

Indexed as

Anti-Bacterial AgentsDrug DesignIsoxazolesComputer SimulationDensity Functional TheoryMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureAnti-Bacterial AgentsIsoxazolesADMETAntibacterial activityDocking molecularDrug designFluoroisoxazolidinesIn silicoMolecular dynamics

Identifiers

PMID40272693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.