Evidence map›Paper›PMID 40272689›Full record

ReviewJournal of fluorescence2025

Transition Metal Complexes as Antibacterial Agents: An Overview.

Nitesh Kumar, Raj Kaushal, Pamita Awasthi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nitesh KumarDepartment of Chemistry, Government College, Jhandutta, District Bilaspur, Himachal Pradesh, 174031, India. niteshnit6@gmail.com.
Raj KaushalDepartment of Chemistry, National Institute of Technology, Hamirpur, Himachal Pradesh, 177005, India.
Pamita AwasthiDepartment of Chemistry, National Institute of Technology, Hamirpur, Himachal Pradesh, 177005, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the vacant d-orbitals, variable oxidation states, and coordination geometries of transition metals, they have a tendency to form complexes with variety of ligands. The effectiveness of these transition metal complexes as therapeutic agents has been demonstrated in various domains, such as antibacterial, anti-cancer, anti-fungal, anti-diabetic, and anti-malarial. We have reviewed the antibacterial investigations of several transition metal complexes spanning last few years in this review. Upon reviewing the literature, it has been found that metal complexes work better against bacteria than free ligands do. Almost, all the investigations in literature review have come to the conclusion that the nature of the ligand, the nature of the metal ion, the metal's oxidation state, coordination behavior, symmetry, and the stability of the complexes are the key factors responsible for the increased antibacterial activity of metal complexes. Furthermore, after complexation, the metal complexes exhibit enhanced lipophilicity and increased facile translocation through the cellular membrane. Additionally, in contrast to free ligands, the stability and antibacterial activity of metal complexes increased as a result of chelation.

Indexed as

Anti-Bacterial AgentsBacteriaCoordination ComplexesTransition ElementsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsCoordination ComplexesTransition ElementsAntibacterialChelationLigandsLipophilicityTransition metals

Identifiers

PMID40272689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.