ArticleNeurosurgical review2025
Resection with intraoperative radiotherapy vs. adjuvant radiotherapy in the treatment of eloquent brain metastases: an analysis of feasibility and safety.
Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Low-energy X-ray intraoperative radiotherapy for brain metastases: a systematic review of efficacy and safety.Journal of neuro-oncology · 2026Pooled it
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThe treatment of motor eloquent brain metastases (BM) harbors an elevated risk of neurological deficits due to possible damage to motor-cortex and tracts. Preserving a good functional and neurological status is crucial to enable comprehensive oncologic treatment. Growing evidence promotes intraoperative radiotherapy (IORT) with low voltage x-rays as alternative to adjuvant external beam radiotherapy (EBRT). Aim of this study is to investigate the safety and feasibility of surgery with IORT in motor eloquent regions compared to adjuvant radiotherapy (RT).
methodsWe performed a retrospective chart review analysis of patients undergoing surgery for motor eloquent BMs at our institution with either IORT or adjuvant RT. All patients were resected under intraoperative neuromonitoring (IONM). We compared patient characteristics, the rate of neurological deficits along with IONM parameters, functional status (KPS) and adverse events (AE) in both groups.
results33 patients were analyzed from which 25 underwent IORT and 8 adjuvant EBRT in motor eloquent BMs. New motor deficits occurred in 7/33 patients without significant difference between both groups after 30 days (IORT 4/25 vs. adj. RT 3/8; Chi [2]-test: p = 0.19). The KPS after surgery did not differ significantly between both groups (IORT: 90% [72.5-90] vs. adj. RT: 80% [70-90]; Mann-Whitney-U-test: p = 0.31). No patient experienced local tumor recurrence or radio necrosis. 9/33 patients experienced postoperative AEs until the 30 day follow up without significantly different rates between both groups (IORT 5/25 vs. adj. RT 4/8; Chi [2]-test: p = 0.09).
conclusion50 kV photon IORT is a safe treatment option for motor eloquent BMs and does not seem to provoke in symptomatic brain irritation.
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