Evidence map›Paper›PMID 40272548›Full record

ArticlePediatric surgery international2025

Screening ultrasound for deep vein thrombosis detection in high-risk pediatric trauma.

Amanda B Witte, Kyle Van Arendonk, Richard A Falcone, Suzanne Moody, Heather A Hartman, Emily Evans, Rajan Thakkar, Kelli N Patterson, Peter C Minneci, Grace Z Mak and 13 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. A Narrative Review on the Approach to Hospital-Acquired Venous Thromboembolism in Pediatric Trauma and Critically Ill ChildrenTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Amanda B WitteChildren's Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA. awitte@mcw.edu.
Kyle Van ArendonkNationwide Children's Hospital, Columbus, OH, USA.
Richard A FalconeCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Suzanne MoodyCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Heather A HartmanC.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
Emily EvansC.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
Rajan ThakkarNationwide Children's Hospital, Columbus, OH, USA.
Kelli N PattersonNationwide Children's Hospital, Columbus, OH, USA.
Peter C MinneciNemours Children's Hospital, Wilmington, DE, USA.
Grace Z MakComer Children's Hospital, The University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Mark B SlidellJohns Hopkins Children's Center, The Johns Hopkins University, Baltimore, MD, USA.
MacKenton JohnsonComer Children's Hospital, The University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Matthew P LandmanRiley Children's Hospital, Indiana University Health, Indianapolis, IN, USA.
Troy A MarkelRiley Children's Hospital, Indiana University Health, Indianapolis, IN, USA.
Charles M LeysAmerican Family Children's Hospital, University of Wisconsin Health, Madison, WI, USA.
Linda Cherney StaffordAmerican Family Children's Hospital, University of Wisconsin Health, Madison, WI, USA.
Jessica DraperAmerican Family Children's Hospital, University of Wisconsin Health, Madison, WI, USA.
David S FoleyNorton Children's Hospital, University of Louisville, Louisville, KY, USA.
Cynthia DownardNorton Children's Hospital, University of Louisville, Louisville, KY, USA.
Tracy M SkaggsNorton Children's Hospital, University of Louisville, Louisville, KY, USA.
Dave R LalChildren's Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA.
Peter F EhrlichC.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
David GourlayChildren's Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVenous thromboembolism (VTE) is a rare but significant complication among high-risk pediatric trauma patients. The NO CLOT study's primary aim was to evaluate the safety of chemical prophylaxis against VTE in high-risk pediatric trauma patients with a secondary aim of evaluating the use of screening venous duplex ultrasound (sUS) to identify deep vein thrombosis (DVT). We hypothesized that sUS would detect asymptomatic DVT at a high rate in high-risk patients.

methodsA prospective multi-institutional study was performed at eight level one pediatric trauma centers from 2019 to 2022. sUS was recommended 7 days after admission for all high-risk trauma patients. Univariate and multivariate analyses were performed.

resultsOf 460 high-risk trauma patients, 64/341 (18.8%) remained admitted on day 7 and underwent sUS. Ten of 64 (15.6%) had a DVT identified on sUS (median of 6.5 [IQR 5.2, 7.0] days after trauma). In 277 patients still admitted on day 7 without sUS performed, 15 (5.4%) developed symptomatic DVT (median of 6.0 [IQR 3.0, 8.0] days after trauma. For the sUS cohort, 9/10 (90%) DVTs were associated with an indwelling central venous line (CVL) and occurred either without chemical prophylaxis use at all in 4/10 (40%) or when initiated more than 24-h post-trauma in 6/10 (60%).

conclusionsIn this high-risk cohort, most DVTs were identified in the first week following injury; however, the majority were asymptomatic. Use of sUS at 1-week post-injury increases DVT detection; however, the clinical consequences of asymptomatic detection of DVT remain unknown. LEVEL OF EVIDENCE: III.

Indexed as

Ultrasonography, Doppler, DuplexVenous ThrombosisWounds and InjuriesAdolescentChildChild, PreschoolFemaleHumansInfantMaleProspective StudiesRisk FactorsTrauma CentersDeep vein thrombosisPediatric traumaScreening ultrasoundVenous thromboembolism

Identifiers

PMID40272548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.