Evidence map›Paper›PMID 40272501›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

A quantitative SPECT/CT metric for diagnosing transthyretin cardiac amyloidosis: multicenter study on biopsy-confirmed cases.

Taku Takaishi, Masaya Kisohara, Ryosuke Horino, Hitomi Kaneko, Naohide Hotta, Kyosuke Mizuno, Takamine Ezaka, Yuto Kitagawa, Sachiko Okochi, Susumu Kobayashi and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Impact of disease-modifying therapy on [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Taku TakaishiDepartment of Radiology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi Mizuho-cho, Mizuho-ku, Nagoya, 467-8602, Aichi, Japan. jomo.oze@gmail.com.ORCID 0000-0002-2105-5268
Masaya KisoharaDepartment of Radiology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi Mizuho-cho, Mizuho-ku, Nagoya, 467-8602, Aichi, Japan.
Ryosuke HorinoDepartment of Radiology, Kariya Toyota General Hospital, Kariya city, Aichi prefecture, Japan.
Hitomi KanekoDepartment of Radiology, Kariya Toyota General Hospital, Kariya city, Aichi prefecture, Japan.
Naohide HottaDepartment of Radiology, Konan Kosei Hospital, Konan city, Aichi prefecture, Japan.
Kyosuke MizunoCentral Radiology Division, Nagoya City University Hospital, Nagoya city, Aichi prefecture, Japan.
Takamine EzakaCentral Radiology Division, Nagoya City University Hospital, Nagoya city, Aichi prefecture, Japan.
Yuto KitagawaCentral Radiology Division, Nagoya City University Hospital, Nagoya city, Aichi prefecture, Japan.
Sachiko OkochiDepartment of Radiology, Konan Kosei Hospital, Konan city, Aichi prefecture, Japan.
Susumu KobayashiDepartment of Radiology, Toyokawa City Hospital, Toyokawa city, Aichi prefecture, Japan.
Masanori KitaseDepartment of Radiology, Kariya Toyota General Hospital, Kariya city, Aichi prefecture, Japan.
Shuichi KitadaDepartment of Cardiology, Nagoya City University Graduate School of Medical Sciences, Nagoya city, Aichi prefecture, Japan.
Misugi UranoDepartment of Radiology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi Mizuho-cho, Mizuho-ku, Nagoya, 467-8602, Aichi, Japan.
Akio HiwatashiDepartment of Radiology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi Mizuho-cho, Mizuho-ku, Nagoya, 467-8602, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose99mTechnetium-pyrophosphate ([

methodsThis multicenter retrospective study enrolled 253 patients who underwent [

resultsAmong 52 patients (31 men; mean age 77) whose biopsy results were available, 11 were diagnosed with ATTR-CM. LW/Ao ratio showed a sensitivity of 100% (11/11), specificity of 97.6% (40/41), and positive likelihood ratio of 41.0. LW/Ao ratio showed higher AUC (0.99; 95% CI: 0.99-1.00) compared to H/CL ratio (AUC = 0.90, p = 0.04) and visual score (AUC = 0.87, p < 0.01). The ICC of LW/Ao ratio was excellent (0.91 ≥ 0.9).

conclusionThe quantitative SPECT/CT metric demonstrated superior diagnostic accuracy for ATTR-CM compared to conventional methods.

Indexed as

Amyloid Neuropathies, FamilialCardiomyopathiesSingle Photon Emission Computed Tomography Computed TomographyAgedAged, 80 and overBiopsyFemaleHumansMaleMiddle AgedRetrospective Studies[99mTc]Tc-PYPCardiac amyloidosisDiagnosisQuantitative SPECTSPECT/CT

Identifiers

PMID40272501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.